%0 Journal Article %A Mancheño-Losa, Mikel %A Lora-Tamayo, Jaime %A Fernandez-Sampedro, Marta %A Rodriguez-Pardo, Dolors %A Muñoz-Mahamud, Ernesto %A Soldevila, Laura %A Palou, Mariona %A Barbero, Jose Maria %A Del-Toro, Maria Dolores %A Iribarren, Jose Antonio %A Benito, Natividad %A Sobrino, Beatriz %A Rico-Nieto, Alicia %A Guio-Carrion, Laura %A Gomez, Lucia %A Escudero-Sanchez, Rosa %A Garcia-Pais, Maria Jose %A Jover-Saenz, Alfredo %A Praena, Julia %A Baraia-Etxaburu, Josu Miren %A Auñon, Alvaro %A Muñez-Rubio, Elena %A Murillo, Oscar %T Prognosis of unexpected positive intraoperative cultures in arthroplasty revision: A large multicenter cohort %D 2021 %U http://hdl.handle.net/10668/22320 %X Background: The positive-intraoperative-cultures-type prosthetic joint infection (PIOC-PJI) is considered when surgical cultures yield microorganisms in presumed aseptic arthroplasty revisions. Herein we assess the risk factors for failure in the largest cohort of PIOC-PJI patients reported to date.Methods: A retrospective, observational, multicenter study was performed during 2007-2017. Surgeries leading to diagnose PIOC-PJI included only one-stage procedures with either complete or partial prosthesis revision. Failure was defined as recurrence caused by the same microorganism.Results: 203 cases were included (age 72 years, 52% females). Coagulase-negative staphylococci (n = 125, 62%) was the main etiology, but some episodes were caused by virulent bacteria (n = 51, 25%). Prosthesis complete and partial revision was performed in 93 (46%) and 110 (54%) cases, respectively. After a median of 3.4 years, failure occurred in 17 episodes (8.4%, 95%CI 5.3-13.1). Partial revision was an independent predictor of failure (HR 3.63; 95%CI 1.03-12.8), adjusted for gram-negative bacilli (GNB) infection (HR 2.68; 95%CI 0.91-7.89) and chronic renal impairment (HR 2.40; 95%CI 0.90-6.44). Treatment with biofilm-active antibiotics (rifampin/fluoroquinolones) had a favorable impact on infections caused by staphylococci and GNB.Conclusion: Overall prognosis of PIOC-PJI is good, but close follow-up is required in cases of partial revision and in infections caused by GNB. %K Prosthetic joint infection %K Infected arthroplasty %K Biofilm %K Foreign-boy infection %K Arthritis %~