RT Journal Article
T1 Incidence of liver damage of uncertain origin in HIV patients not co-infected with HCV/HBV.
A1 Rivero-Juárez, Antonio
A1 Camacho, Angela
A1 Merchante, Nicolás
A1 Pérez-Camacho, Inés
A1 Macias, Juan
A1 Ortiz-Garcia, Carmen
A1 Cifuentes, Celia
A1 Torre-Cisneros, Julián
A1 Peña, José
A1 Pineda, Juan A
A1 Rivero, Antonio
K1 Análisis de la varianza
K1 Hígado graso
K1 Infecciones por VIH
K1 Enfermedades hepáticas
K1 Modelos logísticos
K1 Estudios longitudinales
K1 Incidencia
K1 Estudios prospectivos
AB BACKGROUND AND AIMSSeveral studies have reported that a significant number of HIV patients not co-infected with HCV/HBV develop liver damage of uncertain origin (LDUO). The objective of our study was to evaluate the incidence of and risk factors for the development of LDUO in HIV infected patients not co-infected with HCV/HBV.METHODSProspective longitudinal study that included HIV-infected patients free of previous liver damage and viral hepatitis B or C co-infections. Patients were followed up at 6-monthly intervals. Liver stiffness was measured at each visit. Abnormal liver stiffness (ALS) was defined as a liver stiffness value greater than 7.2 kPa at two consecutive measurements. For patients who developed ALS, a protocol was followed to diagnose the cause of liver damage. Those patients who could not be diagnosed with any specific cause of liver disease were diagnosed as LDUO and liver biopsy was proposed.RESULTS210 patients matched the inclusion criteria and were included. 198 patients completed the study. After a median (Q1-Q3) follow-up of 18 (IQR 12-26) months, 21 patients (10.6%) developed ALS. Of these, fifteen patients were diagnosed as LDUO. The incidence of LDUO was 7.64 cases/100 patient-years. Histological studies were performed on ten (66.6%) patients and all showed liver steatosis. A higher HOMA-IR value and body mass index were independently associated with the development of LDUO.CONCLUSIONWe found a high incidence of LDUO in HIV-infected patients associated with metabolic risk factors. The leading cause of LDUO in our study was non-alcoholic fatty liver disease.
PB BioMed Central
YR 2013
FD 2013-07-18
LK http://hdl.handle.net/10668/1506
UL http://hdl.handle.net/10668/1506
LA en
NO Rivero-Juárez A, Camacho A, Merchante N, Pérez-Camacho I, Macias J, Ortiz-Garcia C, et al. Incidence of liver damage of uncertain origin in HIV patients not co-infected with HCV/HBV. PLoS ONE; 8(7):e68953
NO Journal Article; Research Support, Non-U.S. Gov't;
DS RISalud
RD Jun 4, 2025