TY  - JOUR
AU  - Bodineau, Clément
AU  - Tomé, Mercedes
AU  - Courtois, Sarah
AU  - Costa, Ana S H.
AU  - Sciacovelli, Marco
AU  - Rousseau, Benoit
AU  - Richard, Elodie
AU  - Vacher, Pierre
AU  - Parejo-Pérez, Carlos
AU  - Bessede, Emilie
AU  - Varon, Christine
AU  - Soubeyran, Pierre
AU  - Frezza, Christian
AU  - Murdoch, Piedad Del Socorro
AU  - Villar, Victor H.
AU  - Durán, Raúl V.
PY  - 2021
DO  - 10.1038/s41467-021-25079-4
UR  - http://hdl.handle.net/10668/3934
T2  - Nature Communications
AB  - Glutamoptosis is the induction of apoptotic cell death as a consequence of the aberrant activation of glutaminolysis and mTORC1 signaling during nutritional imbalance in proliferating cells. The role of the bioenergetic sensor AMPK during...
LA  - en
PB  - Springer Nature
KW  - Asparagine
KW  - Cell death
KW  - Cells
KW  - Glutamine
KW  - Growth
KW  - Rôle
KW  - Signal transduction
KW  - Asparagina
KW  - Muerte celular
KW  - Células
KW  - Glutamina
KW  - Crecimiento
KW  - Rol
KW  - Transducción de señales
KW  - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Intracellular Signaling Peptides and Proteins::AMP-Activated Protein Kinases
KW  - Medical Subject Headings::Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Nucleotides::Purine Nucleotides::Adenine Nucleotides::Adenosine Triphosphate
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals
KW  - Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Antineoplastic Agents
KW  - Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Death::Apoptosis
KW  - Medical Subject Headings::Anatomy::Cells::Cells, Cultured::Cell Line::Cell Line, Tumor
KW  - Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Growth Processes::Cell Proliferation
KW  - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Amino Acids::Amino Acids, Basic::Glutamine
KW  - Medical Subject Headings::Anatomy::Cells::Cells, Cultured::Cell Line::Cell Line, Tumor::HCT116 Cells
KW  - Medical Subject Headings::Anatomy::Cells::Cells, Cultured::Cell Line::Cell Line, Transformed::HEK293 Cells
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Mice::Mice, Inbred Strains::Mice, Inbred NOD
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Mice::Mice, Transgenic::Mice, Knockout
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Mice::Mice, Mutant Strains::Mice, SCID
KW  - Medical Subject Headings::Phenomena and Processes::Chemical Phenomena::Chemical Processes::Biochemical Processes::Signal Transduction
TI  - Two parallel pathways connect glutamine metabolism and mTORC1 activity to regulate glutamoptosis
TY  - research article
ER  -