RT Journal Article
T1 Adipose Tissue Redox Microenvironment as a Potential Link between Persistent Organic Pollutants and the 16-Year Incidence of Non-hormone-Dependent Cancer.
A1 Mustieles, Vicente
A1 Pérez-Carrascosa, Francisco M
A1 León, Josefa
A1 Lange, Theis
A1 Bonde, Jens-Peter
A1 Gómez-Peña, Celia
A1 Artacho-Cordón, Francisco
A1 Barrios-Rodríguez, Rocío
A1 Olmedo-Requena, Rocío
A1 Expósito, José
A1 Jiménez-Moleón, José J
A1 Arrebola, Juan P
K1 cancer
K1 organochlorine pesticides
K1 oxidative stress
K1 persistent organic pollutants
K1 polychlorinated biphenyls
AB We aimed to assess the relationships among the adipose tissue's (AT) oxidative microenvironment, in situ accumulated persistent organic pollutant (POP) concentrations, and cancer development. POP and oxidative stress levels were quantified in AT samples from 382 adults recruited within the GraMo cohort (2003-2004) in Granada (Spain). The 16-year cancer incidence was ascertained by reviewing health/administrative databases. Cox-regression models and mediation analyses were performed. The enzymes superoxide dismutase (SOD) and glutathione reductase (GRd) were positively associated with the risk of non-hormone-dependent (NHD) cancer [adjusted hazard ratio (HR) 1.76; 95% confidence interval (CI): 1.17, 2.64 and HR 2.35; 95% CI: 1.41, 3.94, respectively]. After adjustment for covariates, polychlorinated biphenyl-138 (PCB-138) (HR 1.78; 95% CI: 1.03, 3.09), β-hexachlorocyclohexane (β-HCH) (HR 1.70; 95% CI: 1.09, 2.64), and hexachlorobenzene (HR 1.54; 95% CI: 1.02, 2.33) were also positively associated with the risk of NHD cancer. Although confidence intervals included the null value, probably because of the modest number of cancer cases, we observed a potential mediation effect of SOD and GRd on the associations between β-HCH and the risk of NHD tumors (percent mediated = 33 and 47%, respectively). Our results highlight the relevance of human AT's oxidative microenvironment as a predictor of future cancer risk as well as its potential mediating role on POP-related carcinogenesis. Given their novelty, these findings should be interpreted with caution and confirmed in future studies.
YR 2021
FD 2021-06-28
LK https://hdl.handle.net/10668/26202
UL https://hdl.handle.net/10668/26202
LA en
DS RISalud
RD Apr 12, 2025