RT Journal Article
T1 Modulation of the Magnetic Hyperthermia Response Using Different Superparamagnetic Iron Oxide Nanoparticle Morphologies
A1 Reyes-Ortega, Felisa
A1 Delgado, Ángel V.
A1 Iglesias, Guillermo R.
K1 Hyperthermia
K1 ILP
K1 Magnetic nanoparticles
K1 SPION
K1 Nanocubes
K1 Nanorods
K1 SAR
K1 Magnetic fields
K1 Hipertermia
K1 Nanopartículas magnéticas de óxido de hierro
K1 Nanotubos
K1 Campos magnéticos
AB The use of magnetic nanoparticles in hyperthermia, that is, heating induced by alternating magnetic fields, is gaining interest as a non-invasive, free of side effects technique that can be considered as a co-adjuvant of other cancer treatments. Having sufficient control on the field characteristics, within admissible limits, the focus is presently on the magnetic material. In the present contribution, no attempt has been made of using other composition than superparamagnetic iron oxide nanoparticles (SPION), or of applying surface functionalization, which opens a wider range of choices. We have used a hydrothermal synthesis route that allows preparing SPION nanoparticles in the 40 nm size range, with spherical, cuboidal or rod-like shapes, by minor changes in the synthesis steps. The three kinds of particles (an attempt to produce star-shaped colloids yielded hematite) were demonstrated to have the magnetite (or maghemite) crystallinity. Magnetization cycles showed virtually no hysteresis and demonstrated the superparamagnetic nature of the particles, cuboidal ones displaying saturation magnetization comparable to bulk magnetite, followed by rods and spheres. The three types were used as hyperthermia agents using magnetic fields of 20 kA/m amplitude and frequency in the range 136-205 kHz. All samples demonstrated to be able to raise the solution temperature from room values to 45 °C in a mere 60 s. Not all of them performed the same way, though. Cuboidal magnetic nanoparticles (MNPs) displayed the maximum heating power (SAR or specific absorption rate), ranging in fact among the highest reported with these geometries and raw magnetite composition.
PB MDPI
YR 2021
FD 2021-03-03
LK http://hdl.handle.net/10668/4198
UL http://hdl.handle.net/10668/4198
LA en
NO Reyes-Ortega F, Delgado ÁV, Iglesias GR. Modulation of the Magnetic Hyperthermia Response Using Different Superparamagnetic Iron Oxide Nanoparticle Morphologies. Nanomaterials. 2021 Mar 3;11(3):627.
DS RISalud
RD Apr 6, 2025