TY  - JOUR
AU  - Hernández, Rosa
AU  - Jiménez-Luna, Cristina
AU  - Ortiz, Raúl
AU  - Setién, Fernando
AU  - López, Miguel
AU  - Perazzoli, Gloria
AU  - Esteller, Manel
AU  - Berdasco, María
AU  - Prados, Jose
AU  - Melguizo, Consolación
PY  - 2021
DO  - 10.3390/biology10080802
UR  - http://hdl.handle.net/10668/4194
T2  - Biology
AB  - Human adipose-derived mesenchymal stem cells (hASCs) may be used in some nervous system pathologies, although obtaining an adequate degree of neuronal differentiation is an important barrier to their applicability. This requires a deep understanding...
LA  - en
PB  - MDPI
KW  - Mesenchymal stem cells
KW  - Neuronal differentiation
KW  - Epigenetic changes
KW  - Hoxa-5
KW  - CRISPR/ dCas9
KW  - Células madre mesenquimatosas
KW  - Epigénesis genética
KW  - Proteína 9 asociada a CRISPR
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
KW  - Medical Subject Headings::Phenomena and Processes::Chemical Phenomena::Biochemical Phenomena::Molecular Structure::Base Sequence::Repetitive Sequences, Nucleic Acid::Tandem Repeat Sequences::Inverted Repeat Sequences::Clustered Regularly Interspaced...
KW  - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Structures::Genome::Genome Components::Genes::Genes, Essential
KW  - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::Gene Expression Regulation::Epigenesis, Genetic
KW  - Medical Subject Headings::Chemicals and Drugs::Biological Factors::Biological Markers::Biomarkers, Pharmacological
KW  - Medical Subject Headings::Diseases::Nervous System Diseases
KW  - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Biological Therapy::Cell- and Tissue-Based Therapy
KW  - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Intercellular Signaling Peptides and Proteins::Nerve Growth Factors::Neuregulins
TI  - Impact of the Epigenetically Regulated Hoxa-5 Gene in Neural Differentiation from Human Adipose-Derived Stem Cells
TY  - research article
ER  -