RT Journal Article T1 Leisure-time physical activity, sedentary behaviors, sleep, and cardiometabolic risk factors at baseline in the PREDIMED-PLUS intervention trial: A cross-sectional analysis. A1 Rosique-Esteban, Nuria A1 Díaz-Lopez, Andres A1 Martinez-Gonzalez, Miguel A A1 Corella, Dolores A1 Goday, Albert A1 Martinez, J Alfredo A1 Romaguera, Dora A1 Vioque, Jesus A1 Aros, Fernando A1 Garcia-Rios, Antonio A1 Tinahones, Francisco A1 Estruch, Ramon A1 Fernandez-Garcia, Jose Carlos A1 Lapetra, Jose A1 Serra-Majem, Luis A1 Pinto, Xavier A1 Tur, Josep A A1 Bueno-Cavanillas, Aurora A1 Vidal, Josep A1 Delgado-Rodriguez, Miguel A1 Daimiel, Lidia A1 Vazquez, Clotilde A1 Rubio, Miguel Angel A1 Ros, Emilio A1 Salas-Salvado, Jordi K1 Odds ratio K1 Prevalence K1 Risk factors K1 Sedentary behavior K1 Sleep K1 Spain AB Limited data exists on the interrelationships between physical activity (PA), sedentary behaviors and sleep concerning cardiometabolic risk factors in aged adults at high cardiovascular disease risk. Our aim was to examine independent and joint associations between time spent in leisure-time PA, sedentary behaviors and sleep on the prevalence of obesity, type 2 diabetes (T2D) and components of the metabolic syndrome (MetS) in Mediterranean individuals at high cardiovascular risk. Cross-sectional analyses were performed on baseline data from 5776 Spanish adults (aged 55-75y in men; 60-75y in women) with overweight/obesity and MetS, from October 2013 to October 2016, in the PREDIMED-PLUS trial. Employing multivariable-adjusted Cox regression with robust variance and constant time (given the cross-sectional design), higher prevalence of obesity, T2D and abdominal obesity as component of the MetS were associated with greater time in TV-viewing (Relative Risk, RR: 1.02, 95%CI: 1.01, 1.03; RR:1.04, 95%CI: 1.02, 1.06 and RR: 1.01 95%CI: 1.00, 1.02; respectively, all P< .01). Conversely, greater time in moderate-vigorous PA (MVPA) was associated with lower prevalence of obesity, T2D, abdominal obesity and low HDL-cholesterol (RR: 0.95, 95%CI: 0.93, 0.97; RR: 0.94, 95%CI: 0.89, 0.99; RR: 0.97, 95%CI: 0.96,0.98; and RR: 0.95, 95%CI: 0.91, 0.99, respectively, all P < .05). For these outcomes, theoretically substituting 1-h/day of MVPA for 1-h/day TV-viewing was also significantly associated with lower prevalence (RR 0.91 to 0.97, all P < .05). Similar lower RR in these outcomes was observed when substituting 1-h/day of MVPA for 1-h/day of sleeping. Longer time watching TV and not meeting MVPA recommendations were jointly associated with higher RR of the prevalence of obesity and T2D. We concluded that, in senior individuals athigh cardiovascular risk, greater time spent on MVPA and fewer on sedentary behaviors was inversely associated with prevalence of obesity, T2D, and some of the components of MetS. PB Public Library of Science YR 2017 FD 2017-03-08 LK http://hdl.handle.net/10668/10942 UL http://hdl.handle.net/10668/10942 LA en NO Rosique-Esteban N, Díaz-López A, Martínez-González MA, Corella D, Goday A, Martínez JA, et al. Leisure-time physical activity, sedentary behaviors, sleep, and cardiometabolic risk factors at baseline in the PREDIMED-PLUS intervention trial: A cross-sectional analysis. PLoS One. 2017 Mar 8;12(3):e0172253 DS RISalud RD Jul 7, 2025