RT Journal Article
T1 Magnetic resonance imaging before breast cancer surgery: results of an observational multicenter international prospective analysis (MIPA).
A1 Sardanelli, Francesco
A1 Trimboli, Rubina M
A1 Houssami, Nehmat
A1 Gilbert, Fiona J
A1 Helbich, Thomas H
A1 Álvarez Benito, Marina
A1 Balleyguier, Corinne
A1 Bazzocchi, Massimo
A1 Bult, Peter
A1 Calabrese, Massimo
A1 Camps Herrero, Julia
A1 Cartia, Francesco
A1 Cassano, Enrico
A1 Clauser, Paola
A1 Cozzi, Andrea
A1 de Andrade, Danúbia A
A1 de Lima Docema, Marcos F
A1 Depretto, Catherine
A1 Dominelli, Valeria
A1 Forrai, Gábor
A1 Girometti, Rossano
A1 Harms, Steven E
A1 Hilborne, Sarah
A1 Ienzi, Raffaele
A1 Lobbes, Marc B I
A1 Losio, Claudio
A1 Mann, Ritse M
A1 Montemezzi, Stefania
A1 Obdeijn, Inge-Marie
A1 Ozcan, Umit A
A1 Pediconi, Federica
A1 Pinker, Katja
A1 Preibsch, Heike
A1 Raya Povedano, José L
A1 Sacchetto, Daniela
A1 Scaperrotta, Gianfranco P
A1 Schiaffino, Simone
A1 Schlooz, Margrethe
A1 Szabó, Botond K
A1 Taylor, Donna B
A1 Ulus, Özden S
A1 Van Goethem, Mireille
A1 Veltman, Jeroen
A1 Weigel, Stefanie
A1 Wenkel, Evelyn
A1 Zuiani, Chiara
A1 Di Leo, Giovanni
K1 Breast cancer
K1 Breast-conserving surgery
K1 Magnetic resonance imaging
K1 Mastectomy
K1 Reoperation
AB Preoperative breast magnetic resonance imaging (MRI) can inform surgical planning but might cause overtreatment by increasing the mastectomy rate. The Multicenter International Prospective Analysis (MIPA) study investigated this controversial issue. This observational study enrolled women aged 18-80 years with biopsy-proven breast cancer, who underwent MRI in addition to conventional imaging (mammography and/or breast ultrasonography) or conventional imaging alone before surgery as routine practice at 27 centers. Exclusion criteria included planned neoadjuvant therapy, pregnancy, personal history of any cancer, and distant metastases. Of 5896 analyzed patients, 2763 (46.9%) had conventional imaging only (noMRI group), and 3133 (53.1%) underwent MRI that was performed for diagnosis, screening, or unknown purposes in 692/3133 women (22.1%), with preoperative intent in 2441/3133 women (77.9%, MRI group). Patients in the MRI group were younger, had denser breasts, more cancers ≥ 20 mm, and a higher rate of invasive lobular histology than patients who underwent conventional imaging alone (p  Clinicians requested breast MRI for women with a higher a priori probability of receiving mastectomy. MRI was associated with 11.3% more mastectomies, and with 3.2% fewer reoperations in the breast conservation subgroup. • In 19% of patients of the MIPA study, breast MRI was performed for screening or diagnostic purposes. • The current patient selection to preoperative breast MRI implies an 11% increase in mastectomies, counterbalanced by a 3% reduction of the reoperation rate. • Data from the MIPA study can support discussion in tumor boards when preoperative MRI is under consideration and should be shared with patients to achieve informed decision-making.
YR 2021
FD 2021-10-13
LK http://hdl.handle.net/10668/19797
UL http://hdl.handle.net/10668/19797
LA en
DS RISalud
RD Apr 5, 2025