RT Journal Article
T1 Transgenic Mouse Models of Alzheimer's Disease: An Integrative Analysis.
A1 Sanchez-Varo, Raquel
A1 Mejias-Ortega, Marina
A1 Fernandez-Valenzuela, Juan Jose
A1 Nuñez-Diaz, Cristina
A1 Caceres-Palomo, Laura
A1 Vegas-Gomez, Laura
A1 Sanchez-Mejias, Elisabeth
A1 Trujillo-Estrada, Laura
A1 Garcia-Leon, Juan Antonio
A1 Moreno-Gonzalez, Ines
A1 Vizuete, Marisa
A1 Vitorica, Javier
A1 Baglietto-Vargas, David
A1 Gutierrez, Antonia
K1 Alzheimer’s disease
K1 amyloid
K1 astrocytes
K1 microglia
K1 neurodegeneration
K1 oligodendrocytes
K1 tau
K1 transgenic mice
AB Alzheimer's disease (AD) constitutes the most prominent form of dementia among elderly individuals worldwide. Disease modeling using murine transgenic mice was first initiated thanks to the discovery of heritable mutations in amyloid precursor protein (APP) and presenilins (PS) genes. However, due to the repeated failure of translational applications from animal models to human patients, along with the recent advances in genetic susceptibility and our current understanding on disease biology, these models have evolved over time in an attempt to better reproduce the complexity of this devastating disease and improve their applicability. In this review, we provide a comprehensive overview about the major pathological elements of human AD (plaques, tauopathy, synaptic damage, neuronal death, neuroinflammation and glial dysfunction), discussing the knowledge that available mouse models have provided about the mechanisms underlying human disease. Moreover, we highlight the pros and cons of current models, and the revolution offered by the concomitant use of transgenic mice and omics technologies that may lead to a more rapid improvement of the present modeling battery.
YR 2022
FD 2022-05-12
LK http://hdl.handle.net/10668/21157
UL http://hdl.handle.net/10668/21157
LA en
DS RISalud
RD Apr 8, 2025