RT Journal Article
T1 Sex-Dependent Shared and Nonshared Genetic Architecture Across Mood and Psychotic Disorders.
A1 Blokland, Gabriëlla A M
A1 Grove, Jakob
A1 Chen, Chia-Yen
A1 Cotsapas, Chris
A1 Tobet, Stuart
A1 Handa, Robert
A1 Schizophrenia Working Group of the Psychiatric Genomics Consortium, 
A1 St Clair, David
A1 Lencz, Todd
A1 Mowry, Bryan J
A1 Periyasamy, Sathish
A1 Martin, Nicholas G
A1 Fullerton, Janice M
A1 Müller-Myhsok, Bertram
A1 Mitchell, Philip B
A1 Schofield, Peter R
A1 Forstner, Andreas J
A1 Degenhardt, Franziska
A1 Schaupp, Sabrina
A1 Comes, Ashley L
A1 Kogevinas, Manolis
A1 Scott, Laura J
A1 Guzman-Parra, José
A1 Reif, Andreas
A1 Streit, Fabian
A1 Świątkowska, Beata
A1 Sirignano, Lea
A1 Cichon, Sven
A1 Grigoroiu-Serbanescu, Maria
A1 Hauser, Joanna
A1 Lissowska, Jolanta
A1 Schulze, Thomas G
A1 Stahl, Eli A
A1 Nöthen, Markus M
A1 Rietschel, Marcella
A1 Kelsoe, John
A1 Leboyer, Marion
A1 Jamain, Stéphane
A1 Etain, Bruno
A1 Knowles, James A
A1 Bellivier, Frank
A1 Vincent, John B
A1 Alda, Martin
A1 Perlis, Roy H
A1 O'Donovan, Claire
A1 Cervantes, Pablo
A1 Biernacka, Joanna M
A1 Frye, Mark
A1 McElroy, Susan L
A1 Landén, Mikael
A1 Hamshere, Marian L
A1 Smeland, Olav B
A1 Djurovic, Srdjan
A1 Vaaler, Arne E
A1 Andreassen, Ole A
A1 Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, 
A1 Mullins, Niamh
A1 Baune, Bernhard T
A1 Air, Tracy
A1 Preisig, Martin
A1 Lucae, Susanne
A1 Uher, Rudolf
A1 Levinson, Douglas F
A1 Weissman, Myrna M
A1 Potash, James B
A1 Shi, Jianxin
A1 Boomsma, Dorret I
A1 Adams, Mark J
A1 Penninx, Brenda W J H
A1 Hottenga, Jouke-Jan
A1 de Geus, Eco J C
A1 Willemsen, Gonneke
A1 Milaneschi, Yuri
A1 Tiemeier, Henning
A1 Cairns, Murray J
A1 Grabe, Hans J
A1 Teumer, Alexander
A1 Van der Auwera, Sandra
A1 Tooney, Paul A
A1 Völker, Uwe
A1 Hamilton, Steven P
A1 Magnusson, Patrik K E
A1 Viktorin, Alexander
A1 Mehta, Divya
A1 Breen, Gerome
A1 McIntosh, Andrew M
A1 Lewis, Cathryn M
A1 Sex Differences Cross-Disorder Analysis Group of the Psychiatric Genomics Consortium, 
A1 iPSYCH, 
A1 Hougaard, David M
A1 Nordentoft, Merete
A1 Sanders, Alan R
A1 Mors, Ole
A1 Mortensen, Preben B
A1 Werge, Thomas
A1 Wu, Jing Qin
A1 Als, Thomas D
A1 Børglum, Anders D
A1 Petryshen, Tracey L
A1 Smoller, Jordan W
A1 Goldstein, Jill M
A1 Kelly, Brian
A1 Buxbaum, Joseph D
A1 Kirov, George
A1 Sullivan, Patrick F
A1 Corvin, Aiden
A1 Riley, Brien P
A1 Esko, Tõnu
A1 Milani, Lili
A1 Jönsson, Erik G
A1 Palotie, Aarno
A1 Ehrenreich, Hannelore
A1 Begemann, Martin
A1 Rujescu, Dan
A1 Steixner-Kumar, Agnes
A1 Sham, Pak C
A1 Iwata, Nakao
A1 Weinberger, Daniel R
A1 Gejman, Pablo V
A1 Giegling, Ina
A1 Konte, Bettina
A1 Hartmann, Annette M
A1 Bramon, Elvira
A1 Murray, Robin M
A1 Pato, Michele T
A1 Lee, Jimmy
A1 Mayoral, Fermin
A1 Melle, Ingrid
A1 Molden, Espen
A1 Ophoff, Roel A
A1 McQuillin, Andrew
A1 Bass, Nicholas J
A1 Adolfsson, Rolf
A1 Malhotra, Anil K
A1 Bipolar Disorder Working Group of the Psychiatric Genomics Consortium, 
K1 Bipolar disorder
K1 Genome-wide association study
K1 Genotype-by-sex interaction
K1 Major depressive disorder
K1 Schizophrenia
K1 Sex differences
AB Sex differences in incidence and/or presentation of schizophrenia (SCZ), major depressive disorder (MDD), and bipolar disorder (BIP) are pervasive. Previous evidence for shared genetic risk and sex differences in brain abnormalities across disorders suggest possible shared sex-dependent genetic risk. We conducted the largest to date genome-wide genotype-by-sex (G×S) interaction of risk for these disorders using 85,735 cases (33,403 SCZ, 19,924 BIP, and 32,408 MDD) and 109,946 controls from the PGC (Psychiatric Genomics Consortium) and iPSYCH. Across disorders, genome-wide significant single nucleotide polymorphism-by-sex interaction was detected for a locus encompassing NKAIN2 (rs117780815, p = 3.2 × 10-8), which interacts with sodium/potassium-transporting ATPase (adenosine triphosphatase) enzymes, implicating neuronal excitability. Three additional loci showed evidence (p  In the largest genome-wide G×S analysis of mood and psychotic disorders to date, there was substantial genetic overlap between the sexes. However, significant sex-dependent effects were enriched for genes related to neuronal development and immune and vascular functions across and within SCZ, BIP, and MDD at the variant, gene, and pathway levels.
YR 2021
FD 2021-03-23
LK http://hdl.handle.net/10668/22054
UL http://hdl.handle.net/10668/22054
LA en
NO Blokland, G. A. M., Grove, J., Chen, C. Y., Cotsapas, C., Tobet, S., Handa, R., et al. (2022). Sex-Dependent Shared and Nonshared Genetic Architecture Across Mood and Psychotic Disorders. Biological psychiatry, 91(1), 102–117.
DS RISalud
RD Apr 30, 2025