RT Journal Article
T1 Colorectal cancer pain upon diagnosis and after treatment: a cross-sectional comparison with healthy matched controls.
A1 Lopez-Garzon, Maria
A1 Postigo-Martin, Paula
A1 Gonzalez-Santos, Angela
A1 Arroyo-Morales, Manuel
A1 Achalandabaso-Ochoa, Alexander
A1 Fernandez-Perez, Antonio Manuel
A1 Cantarero-Villanueva, Irene
K1 Body composition
K1 Cancer pain
K1 Colorectal cancer
K1 Muscle strength
K1 Pain measurement
AB The current study sought to explore whether cancer pain (CP) already exists in patients at colorectal cancer (CRC) diagnosis before treatment compared with patients with colorectal cancer (CRC) after treatment and a healthy matched control group. The study also sought to examine whether factors related to physical health status could enhance pain processes. An observational cross-sectional study was conducted following the STROBE checklist. Twenty-nine newly diagnosed and forty post-treatment patients with CRC and 40 healthy age/sex-matched controls were included for comparison. Pain, local muscle function, and body composition outcomes were assessed by a physiotherapist with > 3 years of experience. ANCOVA and Kruskal-Wallis tests were performed, with Bonferroni and Dunn-Bonferroni post hoc analyses and Cohen's d and Hedge's effect size, as appropriate. The analysis detected lower values of pressure pain threshold (PPT) points, the PPT index, and abdominal strength and higher values of self-reported abdominal pain in newly diagnosed patients, with even more marked results observed in the post-treatment patients, where lower lean mass and skeletal muscle index values were also found than those in the healthy matched controls (p  Upon diagnosis, patients with CRC already show signs of hyperalgesia and central sensitization and deteriorated physical conditions and body composition, and this state could be aggravated by subsequent treatments.
PB Springer
YR 2021
FD 2021-12-31
LK http://hdl.handle.net/10668/20286
UL http://hdl.handle.net/10668/20286
LA en
NO Lopez-Garzon M, Postigo-Martin P, González-Santos Á, Arroyo-Morales M, Achalandabaso-Ochoa A, Férnández-Pérez AM, et al. Colorectal cancer pain upon diagnosis and after treatment: a cross-sectional comparison with healthy matched controls. Support Care Cancer. 2022 Apr;30(4):3573-3584.
DS RISalud
RD Apr 12, 2025