RT Journal Article
T1 Diet-wide association study of 92 foods and nutrients and lung cancer risk in the European Prospective Investigation into Cancer and Nutrition study and the Netherlands Cohort Study.
A1 Heath, Alicia K
A1 Muller, David C
A1 van den Brandt, Piet A
A1 Critselis, Elena
A1 Gunter, Marc
A1 Vineis, Paolo
A1 Weiderpass, Elisabete
A1 Boeing, Heiner
A1 Ferrari, Pietro
A1 Merritt, Melissa A
A1 Rostgaard-Hansen, Agnetha L
A1 Tjønneland, Anne
A1 Overvad, Kim
A1 Katzke, Verena
A1 Srour, Bernard
A1 Masala, Giovanna
A1 Sacerdote, Carlotta
A1 Ricceri, Fulvio
A1 Pasanisi, Fabrizio
A1 Bueno-de-Mesquita, Bas
A1 Downward, George S
A1 Skeie, Guri
A1 Sandanger, Torkjel M
A1 Crous-Bou, Marta
A1 Rodriguez-Barranco, Miguel
A1 Amiano, Pilar
A1 Huerta, Jose Maria
A1 Ardanaz, Eva
A1 Drake, Isabel
A1 Johansson, Mikael
A1 Johansson, Ingegerd
A1 Key, Tim
A1 Papadimitriou, Nikos
A1 Riboli, Elio
A1 Tzoulaki, Ioanna
A1 Tsilidis, Konstantinos K
K1 cohort study
K1 diet
K1 foods
K1 lung cancer
K1 nutrients
AB It is unclear whether diet, and in particular certain foods or nutrients, are associated with lung cancer risk. We assessed associations of 92 dietary factors with lung cancer risk in 327 790 participants in the European Prospective Investigation into Cancer and Nutrition (EPIC). Cox regression yielded adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) per SD higher intake/day of each food/nutrient. Correction for multiple comparisons was performed using the false discovery rate and identified associations were evaluated in the Netherlands Cohort Study (NLCS). In EPIC, 2420 incident lung cancer cases were identified during a median of 15 years of follow-up. Higher intakes of fibre (HR per 1 SD higher intake/day = 0.91, 95% CI 0.87-0.96), fruit (HR = 0.91, 95% CI 0.86-0.96) and vitamin C (HR = 0.91, 95% CI 0.86-0.96) were associated with a lower risk of lung cancer, whereas offal (HR = 1.08, 95% CI 1.03-1.14), retinol (HR = 1.06, 95% CI 1.03-1.10) and beer/cider (HR = 1.04, 95% CI 1.02-1.07) intakes were positively associated with lung cancer risk. Associations did not differ by sex and there was less evidence for associations among never smokers. None of the six associations with overall lung cancer risk identified in EPIC were replicated in the NLCS (2861 cases), however in analyses of histological subtypes, inverse associations of fruit and vitamin C with squamous cell carcinoma were replicated in the NLCS. Overall, there is little evidence that intakes of specific foods and nutrients play a major role in primary lung cancer risk, but fruit and vitamin C intakes seem to be inversely associated with squamous cell lung cancer.
PB John Wiley & Sons, Inc.
YR 2022
FD 2022-06-02
LK http://hdl.handle.net/10668/22084
UL http://hdl.handle.net/10668/22084
LA en
NO Heath AK, Muller DC, van den Brandt PA, Critselis E, Gunter M, Vineis P, et al. Diet-wide association study of 92 foods and nutrients and lung cancer risk in the European Prospective Investigation into Cancer and Nutrition study and the Netherlands Cohort Study. Int J Cancer. 2022 Dec 1;151(11):1935-1946.
DS RISalud
RD Apr 8, 2025