RT Journal Article
T1 Novel association of five HLA alleles with HIV-1 progression in Spanish long-term non progressor patients.
A1 Ramírez de Arellano, Eva
A1 Díez-Fuertes, Francisco
A1 Aguilar, Francisco
A1 de la Torre Tarazona, Humberto Erick
A1 Sánchez-Lara, Susana
A1 Lao, Yolanda
A1 Vicario, José Luis
A1 García, Felipe
A1 González-Garcia, Juan
A1 Pulido, Federico
A1 Gutierrez-Rodero, Félix
A1 Moreno, Santiago
A1 Iribarren, Jose Antonio
A1 Viciana, Pompeyo
A1 Vilches, Carlos
A1 Ramos, Manuel
A1 Capa, Laura
A1 Alcamí, José
A1 Del Val, Margarita
AB Certain host genetic variants, especially in the human leucocyte antigen (HLA) region, are associated with different progression of HIV-1-induced diseases and AIDS. Long term non progressors (LTNP) represent only the 2% of infected patients but are especially relevant because of their efficient HIV control. In this work we present a global analysis of genetic data in the large national multicenter cohort of Spanish LTNP, which is compared with seronegative individuals and HIV-positive patients. We have analyzed whether several single-nucleotide polymorphisms (SNPs) including in key genes and certain HLA-A and B alleles could be associated with a specific HIV phenotype. A total of 846 individuals, 398 HIV-1-positive patients (213 typical progressors, 55 AIDS patients, and 130 LTNPs) and 448 HIV-negative controls, were genotyped for 15 polymorphisms and HLA-A and B alleles. Significant differences in the allele frequencies among the studied populations identified 16 LTNP-associated genetic factors, 5 of which were defined for the first time as related to LTNP phenotype: the protective effect of HLA-B39, and the detrimental impact of HLA-B18, -A24, -B08 and -A29. The remaining eleven polymorphisms confirmed previous publications, including the protective alleles HLA-B57, rs2395029 (HCP5), HLA bw4 homozygosity, HLA-B52, HLA-B27, CCR2 V64I, rs9264942 (HLA-C) and HLA-A03; and the risk allele HLA bw6 homozygosity. Notably, individual Spanish HIV-negative individuals had an average of 0.12 protective HLA alleles and SNPs, compared with an average of 1.43 protective alleles per LTNP patient, strongly suggesting positive selection of LTNP. Finally, stratification of LTNP according to viral load showed a proportional relationship between the frequency of protective alleles with control of viral load. Interestingly, no differences in the frequency of protection/risk polymorphisms were found between elite controllers and LTNPs maintaining viral loads
YR 2019
FD 2019-08-08
LK http://hdl.handle.net/10668/14379
UL http://hdl.handle.net/10668/14379
LA en
DS RISalud
RD Apr 15, 2025