RT Journal Article T1 Antiplatelet therapy and outcome in COVID-19: the Health Outcome Predictive Evaluation Registry A1 Santoro, Francesco A1 Nunez-Gil, Ivan Javier A1 Vitale, Enrica A1 Viana-Llamas, Maria C. A1 Reche-Martinez, Begona A1 Romero-Pareja, Rodolfo A1 Feltez Guzman, Gisela A1 Fernandez Rozas, Inmaculada A1 Uribarri, Aitor A1 Becerra-Munoz, Victor Manuel A1 Alfonso-Rodriguez, Emilio A1 Garcia-Aguado, Marcos A1 Huang, Jia A1 Ortega-Armas, Maria Elizabeth A1 Garcia Prieto, Juan F. A1 Corral Rubio, Eva Maria A1 Ugo, Fabrizio A1 Bianco, Matteo A1 Mulet, Alba A1 Raposeiras-Roubin, Sergio A1 Jativa Mendez, Jorge Luis A1 Espejo Paeres, Carolina A1 Albarran, Adrian Rodriguez A1 Marin, Francisco A1 Guerra, Federico A1 Akin, Ibrahim A1 Cortese, Bernardo A1 Ramakrishna, Harish A1 Macaya, Carlos A1 Fernandez-Ortiz, Antonio A1 Brunetti, Natale Daniele K1 COVID-19 K1 pharmacology K1 clinical K1 Coronavirus disease 2019 AB Background Standard therapy for COVID-19 is continuously evolving. Autopsy studies showed high prevalence of platelet-fibrin-rich microthrombi in several organs. The aim of the study was therefore to evaluate the safety and efficacy of antiplatelet therapy (APT) in hospitalised patients with COVID-19 and its impact on survival.Methods 7824 consecutive patients with COVID-19 were enrolled in a multicentre international prospective registry (Health Outcome Predictive Evaluation-COVID-19 Registry). Clinical data and in-hospital complications were recorded. Data on APT, including aspirin and other antiplatelet drugs, were obtained for each patient.Results During hospitalisation, 730 (9%) patients received single APT (93%, n=680) or dual APT (7%, n=50). Patients treated with APT were older (74 +/- 12 years vs 63 +/- 17 years, p PB Bmj publishing group SN 1355-6037 YR 2021 FD 2021-10-05 LK https://hdl.handle.net/10668/26896 UL https://hdl.handle.net/10668/26896 LA en DS RISalud RD Apr 5, 2025