RT Journal Article
T1 Endometrial cancer risk prediction including serum-based biomarkers: results from the EPIC cohort.
A1 Fortner, Renée T
A1 Hüsing, Anika
A1 Kühn, Tilman
A1 Konar, Meric
A1 Overvad, Kim
A1 Tjønneland, Anne
A1 Hansen, Louise
A1 Boutron-Ruault, Marie-Christine
A1 Severi, Gianluca
A1 Fournier, Agnès
A1 Boeing, Heiner
A1 Trichopoulou, Antonia
A1 Benetou, Vasiliki
A1 Orfanos, Philippos
A1 Masala, Giovanna
A1 Agnoli, Claudia
A1 Mattiello, Amalia
A1 Tumino, Rosario
A1 Sacerdote, Carlotta
A1 Bueno-de-Mesquita, H B As
A1 Peeters, Petra H M
A1 Weiderpass, Elisabete
A1 Gram, Inger T
A1 Gavrilyuk, Oxana
A1 Quirós, J Ramón
A1 Maria Huerta, José
A1 Ardanaz, Eva
A1 Larrañaga, Nerea
A1 Lujan-Barroso, Leila
A1 Sánchez-Cantalejo, Emilio
A1 Butt, Salma Tunå
A1 Borgquist, Signe
A1 Idahl, Annika
A1 Lundin, Eva
A1 Khaw, Kay-Tee
A1 Allen, Naomi E
A1 Rinaldi, Sabina
A1 Dossus, Laure
A1 Gunter, Marc
A1 Merritt, Melissa A
A1 Tzoulaki, Ioanna
A1 Riboli, Elio
A1 Kaaks, Rudolf
K1 adipokines
K1 cytokines
K1 endometrial cancer
K1 growth factors
K1 inflammatory markers
K1 lipids
K1 metabolic markers
K1 prospective cohort
K1 risk prediction
K1 sex steroids
AB Endometrial cancer risk prediction models including lifestyle, anthropometric and reproductive factors have limited discrimination. Adding biomarker data to these models may improve predictive capacity; to our knowledge, this has not been investigated for endometrial cancer. Using a nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, we investigated the improvement in discrimination gained by adding serum biomarker concentrations to risk estimates derived from an existing risk prediction model based on epidemiologic factors. Serum concentrations of sex steroid hormones, metabolic markers, growth factors, adipokines and cytokines were evaluated in a step-wise backward selection process; biomarkers were retained at p 
YR 2017
FD 2017
LK http://hdl.handle.net/10668/10666
UL http://hdl.handle.net/10668/10666
LA en
DS RISalud
RD Apr 7, 2025