RT Journal Article
T1 Administration of mycophenolic acid is not associated with malformations in descendants from kidney transplanted males.
A1 Lopez-Lopez, Isabel
A1 Rodelo-Haad, Cristian
A1 Agüera, Maria Luisa
A1 Cabello-Jabalquinto, Rosario
A1 Esquivias-Motta, Elvira
A1 Navarro, M Dolores
A1 Aljama, Pedro
A1 Rodriguez-Benot, Alberto
K1 Mycophenolic acid
K1 Pregnancy
K1 Prenatal exposure delayed effects
K1 Renal insufficiency, chronic
K1 Retrospective studies
AB In pregnant women, the use of Mycophenolic acid (MPA) is associated with teratogenicity. Recently, the European Medicines Agency (EMEA) and the Spanish Agency of Medicine and Sanitary Products (AEMPS) warned about the potential teratogenic effects of MPA. These adverse events may occur even in children from males on treatment with MPA. However, evidence of malformations in offsprings of male kidney transplanted patients (KT) exposed to MPA is limited. Thus, the present study aimed to evaluate the incidence of offspring malformations in children of renal transplanted males under MPA. We conducted a retrospective study in which we evaluated the incidence of malformations in descendants from male recipients that were exposed or not to MPA before and at the time of conception. Two groups of patients were evaluated. Those exposed to MPA (MPA group, n = 20) and the non-MPA group (n = 13) that included patients that did not receive AZA (n = 5) and eight that did receive AZA (n = 8) at the time of conception. A total of forty-nine post-transplant conceptions were identified from 33 different renal transplanted males. MPA was used as the immunosuppressant in 28 of the conceptions. Males from the non-MPA group fathered the other 21 children. Median time from grafting to conception was 6.1 (IQR 2.4-11.1) years, and it was similar between groups. There were eight miscarriage episodes, 2 in the non-MPA group and 6 in the MPA group although differences were not reached. After that, all patients had children without problems. No malformations were detected in any of the 49 regardless whether they were exposed or not to MPA. No evidence of MPA-associated malformations was observed in descendants of kidney transplanted males on treatment with MPA. Further research is warranted to confirm our findings to properly advice transplanted males keen to procreate.
PB Public Library of Science
YR 2018
FD 2018-08-06
LK http://hdl.handle.net/10668/12934
UL http://hdl.handle.net/10668/12934
LA en
NO Lopez-Lopez I, Rodelo-Haad C, Agüera ML, Cabello-Jabalquinto R, Esquivias-Motta E, Navarro MD, et al. Administration of mycophenolic acid is not associated with malformations in descendants from kidney transplanted males. PLoS One. 2018 Sep 12;13(9):e0202589
DS RISalud
RD Apr 18, 2025