TY - JOUR AU - Tumini, Emanuela AU - Herrera-Moyano, Emilia AU - San Martín-Alonso, Marta AU - Barroso, Sonia AU - Galmarini, Carlos M AU - Aguilera, Andrés PY - 2018 DO - 10.1158/1541-7786.MCR-18-0575 UR - http://hdl.handle.net/10668/13311 T2 - Molecular cancer research : MCR AB - R-loops are a major source of replication stress, DNA damage, and genome instability, which are major hallmarks of cancer cells. Accordingly, growing evidence suggests that R-loops may also be related to cancer. Here we show that R-loops play an... LA - en KW - Carbolines KW - Cell Proliferation KW - DNA Replication KW - Genomic Instability KW - HeLa Cells KW - Heterocyclic Compounds, 4 or More Rings KW - Humans KW - Trabectedin TI - The Antitumor Drugs Trabectedin and Lurbinectedin Induce Transcription-Dependent Replication Stress and Genome Instability. TY - research article VL - 17 ER -