RT Journal Article
T1 Total Effective Xenoestrogen Burden in Serum Samples and Risk for Breast Cancer in a Population-Based Multicase-Control Study in Spain.
A1 Pastor-Barriuso, Roberto
A1 Fernández, Mariana F
A1 Castaño-Vinyals, Gemma
A1 Whelan, Denis
A1 Pérez-Gómez, Beatriz
A1 Llorca, Javier
A1 Villanueva, Cristina M
A1 Guevara, Marcela
A1 Molina-Molina, José-Manuel
A1 Artacho-Cordón, Francisco
A1 Barriuso-Lapresa, Laura
A1 Tusquets, Ignasi
A1 Dierssen-Sotos, Trinidad
A1 Aragonés, Nuria
A1 Olea, Nicolás
A1 Kogevinas, Manolis
A1 Pollán, Marina
AB Most studies on endocrine-disrupting chemicals and breast cancer have focused on single compounds and have produced inconclusive findings. We assessed the combined estrogenic effects of mixtures of xenoestrogens in serum and their relationship to breast cancer risk. A total of 186 incident pretreatment breast cancer cases and 196 frequency-matched controls were randomly sampled from a large population-based multicase-control study in Spain. The total effective xenoestrogen burden attributable to organohalogenated xenoestrogens (TEXB-α) and endogenous hormones and more polar xenoestrogens (TEXB-β) was determined in serum samples using high-performance liquid chromatography and E-Screen bioassay. Odds ratios for breast cancer comparing tertiles of serum TEXB-α and TEXB-β were estimated using logistic models, and smooth risk trends were obtained using spline models. Cases had higher geometric mean TEXB-α and TEXB-β levels (8.32 and 9.94 Eeq pM/mL, respectively) than controls (2.99 and 5.96 Eeq pM/mL, respectively). The fully adjusted odds ratios for breast cancer (95% confidence intervals) comparing the second and third tertiles of TEXB-α with the first tertile were 1.77 (0.76, 4.10) and 3.45 (1.50, 7.97), respectively, and those for TEXB-β were 2.35 (1.10, 5.03) and 4.01 (1.88, 8.56), respectively. A steady increase in risk was evident across all detected TEXB-α levels and a sigmoidal trend was observed for TEXB-β. Individual xenoestrogens showed weak and opposing associations with breast cancer risk. This is the first study to show a strong positive association between serum total xenoestrogen burden and breast cancer risk, highlighting the importance of evaluating xenoestrogen mixtures, rather than single compounds, when studying hormone-related cancers. Pastor-Barriuso R, Fernández MF, Castaño-Vinyals G, Whelan D, Pérez-Gómez B, Llorca J, Villanueva CM, Guevara M, Molina-Molina JM, Artacho-Cordón F, Barriuso-Lapresa L, Tusquets I, Dierssen-Sotos T, Aragonés N, Olea N, Kogevinas M, Pollán M. 2016. Total effective xenoestrogen burden in serum samples and risk for breast cancer in a population-based multicase-control study in Spain. Environ Health Perspect 124:1575-1582; http://dx.doi.org/10.1289/EHP157.
YR 2016
FD 2016-05-20
LK https://hdl.handle.net/10668/28116
UL https://hdl.handle.net/10668/28116
LA en
DS RISalud
RD Apr 17, 2025