TY  - JOUR
AU  - Vida, Margarita
AU  - Gavito, Ana Luisa
AU  - Pavón, Francisco Javier
AU  - Bautista, Dolores
AU  - Serrano, Antonia
AU  - Suarez, Juan
AU  - Arrabal, Sergio
AU  - Decara, Juan
AU  - Romero-Cuevas, Miguel
AU  - Rodríguez de Fonseca, Fernando
AU  - Baixeras, Elena
PY  - 2015
DO  - 10.1242/dmm.019166
SN  - 1754-8403
UR  - http://hdl.handle.net/10668/2233
T2  - Disease Models & Mechanisms
AB  - Interleukin-6 (IL-6) has emerged as an important mediator of fatty acid metabolism with paradoxical effects in the liver. Administration of IL-6 has been reported to confer protection against steatosis, but plasma and tissue IL-6 concentrations are...
LA  - en
PB  - Company of Biologists
KW  - Liver
KW  - Lipogenesis
KW  - Steatosis
KW  - Interleukin-6
KW  - Modelos de enfermedad en animales
KW  - Ácido graso sintasa tipo I
KW  - Células Hep G2
KW  - Interleucina-6
KW  - Lipogénesis
KW  - Hígado
KW  - Ratones
KW  - Ratones consanguíneos C57BL
KW  - Ratones noqueados
KW  - Esteatosis hepática no alcohólica
KW  - Fosforilación
KW  - Proteínas recombinantes
KW  - Factor de transcripción STAT3
KW  - Estearoil-CoA desaturasa
KW  - Supresor de proteínas señalizadoras de citocinas
KW  - Citoquinesis
KW  - Carnitina O-palmitoiltransferasa
KW  - Acetil-CoA carboxilasa
KW  - Alimentación rica en grasa
KW  - Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Ligases::Carbon-Carbon Ligases::Acetyl-CoA Carboxylase
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals
KW  - Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Transferases::Acyltransferases::Carnitine Acyltransferases::Carnitine O-Palmitoyltransferase
KW  - Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Cycle::Cell Division::Cytokinesis
KW  - Medical Subject Headings::Phenomena and Processes::Physiological Phenomena::Nutritional Physiological Phenomena::Diet::Diet, High-Fat
KW  - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Models, Animal::Disease Models, Animal
KW  - Medical Subject Headings::Anatomy::Cells::Epithelial Cells::Hepatocytes::Hep G2 Cells
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
KW  - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Peptides::Intercellular Signaling Peptides and Proteins::Cytokines::Interleukins::Interleukin-6
KW  - Medical Subject Headings::Phenomena and Processes::Metabolic Phenomena::Metabolism::Lipid Metabolism::Lipogenesis
KW  - Medical Subject Headings::Anatomy::Digestive System::Liver
KW  - Medical Subject Headings::Check Tags::Male
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Mice
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals::Animal Population Groups::Animals, Laboratory::Animals, Inbred Strains::Mice, Inbred Strains::Mice, Inbred C57BL
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals::Animal Population Groups::Animals, Genetically Modified::Mice, Transgenic::Mice, Knockout
KW  - Medical Subject Headings::Phenomena and Processes::Metabolic Phenomena::Metabolism::Phosphorylation
KW  - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Recombinant Proteins
KW  - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Transcription Factors::STAT Transcription Factors::STAT3 Transcription Factor
KW  - Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Oxidoreductases::Oxygenases::Mixed Function Oxygenases::Fatty Acid Desaturases::Stearoyl-CoA Desaturase
KW  - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Intracellular Signaling Peptides and Proteins::Adaptor Proteins, Signal Transducing::Suppressor of Cytokine Signaling Proteins
KW  - Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Transferases::Phosphotransferases::Phosphotransferases (Alcohol Group Acceptor)::Protein Kinases::Protein-Serine-Threonine Kinases::AMP-Activated Protein Kinases
KW  - Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Multifunctional Enzymes::Fatty Acid Synthase, Type I
KW  - Medical Subject Headings::Diseases::Digestive System Diseases::Liver Diseases::Fatty Liver::Non-alcoholic Fatty Liver Disease
TI  - Chronic administration of recombinant IL-6 upregulates lipogenic enzyme expression and aggravates high-fat-diet-induced steatosis in IL-6-deficient mice.
TY  - research article
ER  -