RT Journal Article
T1 Morbid Obesity in Women Is Associated with an Altered Intestinal Expression of Genes Related to Cancer Risk and Immune, Defensive, and Antimicrobial Response.
A1 Ho-Plágaro, Ailec
A1 Rodríguez-Díaz, Cristina
A1 Santiago-Fernández, Concepción
A1 López-Gómez, Carlos
A1 García-Serrano, Sara
A1 Martín-Reyes, Flores
A1 Rodríguez-Pacheco, Francisca
A1 Rodríguez-Cañete, Alberto
A1 Alcaín-Martínez, Guillermo
A1 Vázquez-Pedreño, Luis
A1 Valdés, Sergio
A1 Garrido-Sánchez, Lourdes
A1 García-Fuentes, Eduardo
K1 cancer
K1 duodenum
K1 immune system
K1 inflammation
K1 insulin resistance
K1 microarray
K1 morbid obesity
AB Little is known about the relation between morbid obesity and duodenal transcriptomic changes. We aimed to identify intestinal genes that may be associated with the development of obesity regardless of the degree of insulin resistance (IR) of patients. Duodenal samples were assessed by microarray in three groups of women: non-obese women and women with morbid obesity with low and high IR. We identified differentially expressed genes (DEGs) associated with morbid obesity, regardless of IR degree, related to digestion and lipid metabolism, defense response and inflammatory processes, maintenance of the gastrointestinal epithelium, wound healing and homeostasis, and the development of gastrointestinal cancer. However, other DEGs depended on the IR degree. We mainly found an upregulation of genes involved in the response to external organisms, hypoxia, and wound healing functions in women with morbid obesity and low IR. Regardless of the degree of IR, morbid obesity is associated with an altered expression of genes related to intestinal defenses, antimicrobial and immune responses, and gastrointestinal cancer. Our data also suggest a deficient duodenal immune and antimicrobial response in women with high IR.
SN 2227-9059
YR 2022
FD 2022-04-29
LK http://hdl.handle.net/10668/20828
UL http://hdl.handle.net/10668/20828
LA en
DS RISalud
RD Apr 11, 2025