%0 Journal Article
%A Pérez-Beteta, Julián
%A Molina-García, David
%A Ortiz-Alhambra, José A
%A Fernández-Romero, Antonio
%A Luque, Belén
%A Arregui, Elena
%A Calvo, Manuel
%A Borrás, José M
%A Meléndez, Bárbara
%A Rodríguez de Lope, Ángel
%A Moreno de la Presa, Raquel
%A Iglesias Bayo, Lidia
%A Barcia, Juan A
%A Martino, Juan
%A Velásquez, Carlos
%A Asenjo, Beatriz
%A Benavides, Manuel
%A Herruzo, Ismael
%A Revert, Antonio
%A Arana, Estanislao
%A Pérez-García, Víctor M
%T Tumor Surface Regularity at MR Imaging Predicts Survival and Response to Surgery in Patients with Glioblastoma.
%D 2018
%U http://hdl.handle.net/10668/12622
%X Purpose To evaluate the prognostic and predictive value of surface-derived imaging biomarkers obtained from contrast material-enhanced volumetric T1-weighted pretreatment magnetic resonance (MR) imaging sequences in patients with glioblastoma multiforme. Materials and Methods A discovery cohort from five local institutions (165 patients; mean age, 62 years ± 12 [standard deviation]; 43% women and 57% men) and an independent validation cohort (51 patients; mean age, 60 years ± 12; 39% women and 61% men) from The Cancer Imaging Archive with volumetric T1-weighted pretreatment contrast-enhanced MR imaging sequences were included in the study. Clinical variables such as age, treatment, and survival were collected. After tumor segmentation and image processing, tumor surface regularity, measuring how much the tumor surface deviates from a sphere of the same volume, was obtained. Kaplan-Meier, Cox proportional hazards, correlations, and concordance indexes were used to compare variables and patient subgroups. Results Surface regularity was a powerful predictor of survival in the discovery (P = .005, hazard ratio [HR] = 1.61) and validation groups (P = .05, HR = 1.84). Multivariate analysis selected age and surface regularity as significant variables in a combined prognostic model (P
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