RT Journal Article
T1 Graph based study of allergen cross-reactivity of plant lipid transfer proteins (LTPs) using microarray in a multicenter study.
A1 Palacín, Arantxa
A1 Gómez-Casado, Cristina
A1 Rivas, Luis A
A1 Aguirre, Jacobo
A1 Tordesillas, Leticia
A1 Bartra, Joan
A1 Blanco, Carlos
A1 Carrillo, Teresa
A1 Cuesta-Herranz, Javier
A1 Frutos, Consolación de
A1 García Alvarez-Eire, Genoveva
A1 Fernández, Francisco J
A1 Gamboa, Pedro
A1 Muñoz, Rosa
A1 Sánchez-Monge, Rosa
A1 Sirvent, Sofía
A1 Torres, María J
A1 Varela-Losada, Susana
A1 Rodríguez, Rosalía
A1 Parro, Victor
A1 Blanca, Miguel
A1 Salcedo, Gabriel
A1 Díaz-Perales, Araceli
K1 Reacciones Cruzadas
K1 Estudios multicéntricos como asunto
K1 Hipersensibilidad
K1 Análisis de micromatrices
K1 Inmunoanálisis
K1 España
AB The study of cross-reactivity in allergy is key to both understanding. the allergic response of many patients and providing them with a rational treatment In the present study, protein microarrays and a co-sensitization graph approach were used in conjunction with an allergen microarray immunoassay. This enabled us to include a wide number of proteins and a large number of patients, and to study sensitization profiles among members of the LTP family. Fourteen LTPs from the most frequent plant food-induced allergies in the geographical area studied were printed into a microarray specifically designed for this research. 212 patients with fruit allergy and 117 food-tolerant pollen allergic subjects were recruited from seven regions of Spain with different pollen profiles, and their sera were tested with allergen microarray. This approach has proven itself to be a good tool to study cross-reactivity between members of LTP family, and could become a useful strategy to analyze other families of allergens.
PB Public Library of Science
YR 2012
FD 2012-12-14
LK http://hdl.handle.net/10668/1212
UL http://hdl.handle.net/10668/1212
LA en
NO Palacín A, Gómez-Casado C, Rivas LA, Aguirre J, Tordesillas L, Bartra J, et al. Graph based study of allergen cross-reactivity of plant lipid transfer proteins (LTPs) using microarray in a multicenter study. PLoS ONE. 2012; 7(12):e50799
DS RISalud
RD Apr 17, 2025