%0 Journal Article
%A Palacín, Arantxa
%A Gómez-Casado, Cristina
%A Rivas, Luis A
%A Aguirre, Jacobo
%A Tordesillas, Leticia
%A Bartra, Joan
%A Blanco, Carlos
%A Carrillo, Teresa
%A Cuesta-Herranz, Javier
%A Frutos, Consolación de
%A García Alvarez-Eire, Genoveva
%A Fernández, Francisco J
%A Gamboa, Pedro
%A Muñoz, Rosa
%A Sánchez-Monge, Rosa
%A Sirvent, Sofía
%A Torres, María J
%A Varela-Losada, Susana
%A Rodríguez, Rosalía
%A Parro, Victor
%A Blanca, Miguel
%A Salcedo, Gabriel
%A Díaz-Perales, Araceli
%T Graph based study of allergen cross-reactivity of plant lipid transfer proteins (LTPs) using microarray in a multicenter study.
%D 2012
%U http://hdl.handle.net/10668/1212
%X The study of cross-reactivity in allergy is key to both understanding. the allergic response of many patients and providing them with a rational treatment In the present study, protein microarrays and a co-sensitization graph approach were used in conjunction with an allergen microarray immunoassay. This enabled us to include a wide number of proteins and a large number of patients, and to study sensitization profiles among members of the LTP family. Fourteen LTPs from the most frequent plant food-induced allergies in the geographical area studied were printed into a microarray specifically designed for this research. 212 patients with fruit allergy and 117 food-tolerant pollen allergic subjects were recruited from seven regions of Spain with different pollen profiles, and their sera were tested with allergen microarray. This approach has proven itself to be a good tool to study cross-reactivity between members of LTP family, and could become a useful strategy to analyze other families of allergens.
%K Reacciones Cruzadas
%K Estudios multicéntricos como asunto
%K Hipersensibilidad
%K Análisis de micromatrices
%K Inmunoanálisis
%K España
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