%0 Journal Article
%A Sanchez-Larsen, Alvaro
%A Conde-Blanco, Estefanía
%A Viloria-Alebesque, Alejandro
%A Sánchez-Vizcaíno Buendía, Cristina
%A Espinosa Oltra, Tatiana
%A Alvarez-Noval, Amanda
%A Aledo-Serrano, Angel
%A Martin-Garcia, Raquel
%A Ramos-Araque, María E
%A Campos, Dulce
%A Valle-Peñacoba, Gonzalo
%A Sierra-Gómez, Alicia
%A De Ceballos-Cerrajería, Pablo
%A Agundez-Sarasola, Marta
%A Khawaja, Mariam
%A Hampel, Kevin G
%A Serra-Martínez, Maria
%A Arbós-Barber, Clara
%A Gómez-Ibáñez, Asier
%A Villino-Boquete, Rafael
%A Cabezudo-García, Pablo
%A Rodríguez-Lavado, Ignacio
%A Principe, Alessandro
%A Sopelana-Garay, David
%T COVID-19 prevalence and mortality in people with epilepsy: A nation-wide multicenter study.
%D 2021
%U https://hdl.handle.net/10668/24531
%X To assess the prevalence, severity, and mortality of COVID-19 in people with epilepsy (PWE) and evaluate seizure control in PWE during and after COVID-19. Retrospective, observational, multicenter study conducted in 14 hospitals. Medical records of randomly selected PWE followed at neurology outpatient clinics were reviewed. Proportion of PWE with a positive test for SARS-CoV-2 during 2020 was calculated. Risk factors associated with COVID-19 and its morbimortality were evaluated. 2751 PWE were included, mean age 48.8 years (18-99), 72.4% had focal epilepsy, and 35% were drug-refractory. COVID-19 prevalence in PWE was 5.53%, while in the Spanish population was 4.26%. Proportion of admissions to hospital, ICU, and deaths in PWE were 17.1%, 2%, and 4.61% of COVID-19 cases, while in Spanish population were 10.81%, 0.95%, and 2.57%, respectively. A severe form of COVID-19 occurred in 11.8%; dyslipidemia, institutionalization at long-term care facilities, intellectual disability, and older age were associated risk factors. Older age, hypertension, dyslipidemia, cardiac disease, and institutionalization were associated with mortality from COVID-19. Seizure control was stable in 90.1% of PWE during acute COVID-19, while 8.6% reported an increase in seizure frequency. During post-COVID-19 follow-up, 4.6% reported seizure control worsening. COVID-19 was moderately prevalent in PWE. One out of 5 patients required medical attention and 4.6% died due to COVID-19. Older age, dyslipidemia, institutionalization, and intellectual disability were significant risk factors associated with severe COVID-19. Seizure control remained stable during COVID-19 and throughout long-term follow-up in most PWE who contracted the infection.
%K COVID-19
%K Coronavirus, SARS-CoV-2
%K Epilepsy
%K Prevalence
%K Seizures
%~