RT Journal Article
T1 Analysis of Both Lipid Metabolism and Endocannabinoid Signaling Reveals a New Role for Hypothalamic Astrocytes in Maternal Caloric Restriction-Induced Perinatal Programming
A1 Tovar, Rubén
A1 Vargas, Antonio
A1 Aranda, Jesús
A1 Sánchez-Salido, Lourdes
A1 González-González, Laura
A1 Chowen, Julie A.
A1 Rodríguez de Fonseca, Fernando
A1 Suárez, Juan
A1 Rivera, Patricia
K1 Perinatal programming
K1 Hypothalamus
K1 Astrocytes
K1 Endocannabinoid system
K1 Lipid metabolism
K1 Atención perinatal
K1 Hipotálamo
K1 Astrocitos
K1 Endocannabinoides
K1 Metabolismo de los lípidos
AB Maternal malnutrition in critical periods of development increases the risk of developing short- and long-term diseases in the offspring. The alterations induced by this nutritional programming in the hypothalamus of the offspring are of special relevance due to its role in energy homeostasis, especially in the endocannabinoid system (ECS), which is involved in metabolic functions. Since astrocytes are essential for neuronal energy efficiency and are implicated in brain endocannabinoid signaling, here we have used a rat model to investigate whether a moderate caloric restriction (R) spanning from two weeks prior to the start of gestation to its end induced changes in offspring hypothalamic (a) ECS, (b) lipid metabolism (LM) and/or (c) hypothalamic astrocytes. Monitorization was performed by analyzing both the gene and protein expression of proteins involved in LM and ECS signaling. Offspring born from caloric-restricted mothers presented hypothalamic alterations in both the main enzymes involved in LM and endocannabinoids synthesis/degradation. Furthermore, most of these changes were similar to those observed in hypothalamic offspring astrocytes in culture. In conclusion, a maternal low caloric intake altered LM and ECS in both the hypothalamus and its astrocytes, pointing to these glial cells as responsible for a large part of the alterations seen in the total hypothalamus and suggesting a high degree of involvement of astrocytes in nutritional programming.
PB MDPI
YR 2021
FD 2021-06-11
LK http://hdl.handle.net/10668/3956
UL http://hdl.handle.net/10668/3956
LA en
NO Tovar R, Vargas A, Aranda J, Sánchez-Salido L, González-González L, Chowen JA, et al. Analysis of Both Lipid Metabolism and Endocannabinoid Signaling Reveals a New Role for Hypothalamic Astrocytes in Maternal Caloric Restriction-Induced Perinatal Programming. Int J Mol Sci. 2021 Jun 11;22(12):6292
DS RISalud
RD Apr 8, 2025