RT Journal Article
T1 Human Mesenchymal Stem Cells Prevent Neurological Complications of Radiotherapy
A1 Soria, Bernat
A1 Martin-Montalvo, Alejandro
A1 Aguilera, Yolanda
A1 Mellado-Damas, Nuria
A1 López-Beas, Javier
A1 Herrera-Herrera, Isabel
A1 López, Escarlata
A1 Barcia, Juan A.
A1 Alvarez-Dolado, Manuel
A1 Hmadcha, Abdelkrim
A1 Capilla-González, Vivian
K1 Radiotherapy
K1 Stem cells
K1 Cognition
K1 Neuroprotection
K1 Intranasal cell delivery
K1 CREB
K1 Neurocognitive sequelae
K1 Brain cancer
K1 Radioterapia
K1 Células madre
K1 Cognición
K1 Neuroprotección
K1 Neoplasias encefálicas
AB Radiotherapy is a highly effective tool for the treatment of brain cancer. However, radiation also causes detrimental effects in the healthy tissue, leading to neurocognitive sequelae that compromise the quality of life of brain cancer patients. Despite the recognition of this serious complication, no satisfactory solutions exist at present. Here we investigated the effects of intranasal administration of human mesenchymal stem cells (hMSCs) as a neuroprotective strategy for cranial radiation in mice. Our results demonstrated that intranasally delivered hMSCs promote radiation-inducedbrain injury repair, improving neurological function. This intervention confers protection against inflammation, oxidative stress, and neuronal loss. hMSC administration reduces persistent activation of damage-induced c-AMP response element-binding signaling in irradiated brains. Furthermore, hMSC treatment did not compromise the survival of glioma-bearing mice. Our findings encourage the therapeutic use of hMSCs as a non-invasive approach to prevent neurological complications of radiotherapy, improving the quality of life of brain tumor patients.
PB Frontiers Research Foundation
YR 2019
FD 2019-05-16
LK http://hdl.handle.net/10668/3004
UL http://hdl.handle.net/10668/3004
LA es
NO Soria B, Martin-Montalvo A, Aguilera Y, Mellado-Damas N, López-Beas J, Herrera-Herrera I, et al. (2019) Human Mesenchymal Stem Cells Prevent Neurological Complications of Radiotherapy. Front. Cell. Neurosci. 13:204. doi: 10.3389/fncel.2019.00204
DS RISalud
RD Apr 11, 2025