RT Journal Article
T1 Exosomes as diagnostic and predictive biomarkers in lung cancer.
A1 Reclusa, Pablo
A1 Taverna, Simona
A1 Pucci, Marzia
A1 Durendez, Elena
A1 Calabuig, Silvia
A1 Manca, Paolo
A1 Serrano, María José
A1 Sober, Laure
A1 Pauwels, Patrick
A1 Russo, Antonio
A1 Rolfo, Christian
K1 Exosomes
K1 biomarkers
K1 drug resistance
K1 liquid biopsies
K1 non-small cell lung cancer (NSCLC)
AB The concept of exosomes has evolved from be considered garbage bags to the demonstration that exosomes could play very interesting roles and functions, from biomarkers detection to the potential of work as drug delivery systems. It has been widely proved that exosomes can contain key molecules important for the tumour development. The current review summarizes the latest investigations developed in the field of predictive exosomal biomarkers. The microRNAs (miRNAs) are the more known molecules due to their amount inside the exosomes and the sensitivity of the techniques available for their study. However, exosomal proteins, RNA and DNA are becoming an interesting and more feasible field of study due to the improvement in the techniques available for their analysis. In the future years, it is hoped that exosomes will become an established member of the liquid biopsies in the clinical practice due to their diagnostic and prognostic properties.
SN 2072-1439
YR 2017
FD 2017
LK http://hdl.handle.net/10668/11851
UL http://hdl.handle.net/10668/11851
LA en
DS RISalud
RD May 21, 2025