RT Journal Article
T1 Differential patterns of gray matter volumes and associated gene expression profiles in cognitively-defined Alzheimer's disease subgroups.
A1 Groot, Colin
A1 Grothe, Michel J
A1 Mukherjee, Shubhabrata
A1 Jelistratova, Irina
A1 Jansen, Iris
A1 van Loenhoud, Anna Catharina
A1 Risacher, Shannon L
A1 Saykin, Andrew J
A1 Mac Donald, Christine L
A1 Mez, Jesse
A1 Trittschuh, Emily H
A1 Gryglewski, Gregor
A1 Lanzenberger, Rupert
A1 Pijnenburg, Yolande A L
A1 Barkhof, Frederik
A1 Scheltens, Philip
A1 van der Flier, Wiesje M
A1 Crane, Paul K
A1 Ossenkoppele, Rik
K1 Alzheimer’s disease
K1 Gene expression
K1 Gray matter volumes
K1 Heterogeneity
K1 Psychometrics
AB The clinical presentation of Alzheimer's disease (AD) varies widely across individuals but the neurobiological mechanisms underlying this heterogeneity are largely unknown. Here, we compared regional gray matter (GM) volumes and associated gene expression profiles between cognitively-defined subgroups of amyloid-β positive individuals clinically diagnosed with AD dementia (age: 66 ± 7, 47% male, MMSE: 21 ± 5). All participants underwent neuropsychological assessment with tests covering memory, executive-functioning, language and visuospatial-functioning domains. Subgroup classification was achieved using a psychometric framework that assesses which cognitive domain shows substantial relative impairment compared to the intra-individual average across domains, which yielded the following subgroups in our sample; AD-Memory (n = 41), AD-Executive (n = 117), AD-Language (n = 33), AD-Visuospatial (n = 171). We performed voxel-wise contrasts of GM volumes derived from 3Tesla structural MRI between subgroups and controls (n = 127, age 58 ± 9, 42% male, MMSE 29 ± 1), and observed that differences in regional GM volumes compared to controls closely matched the respective cognitive profiles. Specifically, we detected lower medial temporal lobe GM volumes in AD-Memory, lower fronto-parietal GM volumes in AD-Executive, asymmetric GM volumes in the temporal lobe (left 
YR 2021
FD 2021-04-03
LK http://hdl.handle.net/10668/17629
UL http://hdl.handle.net/10668/17629
LA en
DS RISalud
RD Apr 7, 2025