RT Journal Article
T1 Highly water-stable rare ternary Ag-Au-Se nanocomposites as long blood circulation time X-ray computed tomography contrast agents.
A1 Caro, Carlos
A1 Dalmases, Mariona
A1 Figuerola, Albert
A1 García-Martín, María Luisa
A1 Leal, Manuel Pernia
AB X-ray computed tomography (CT) is a powerful and widely used medical non-invasive technique that often requires intravenous administration of contrast agents (CAs) to better visualize soft tissues. In this work, we have developed a novel CT contrast agent based on ternary Ag-Au-Se chalcogenide nanoparticles (NP). A facile ligand exchange by using a 3 kDa PEGylated ligand with a dithiol dihydrolipoic acid as an anchor group resulted in highly water-soluble and monodisperse nanoparticles. These PEGylated ternary NPs were tested in vivo in mice, showing slow uptake by the mononuclear phagocyte system, long blood circulation times, low toxicity, and very good X-ray contrast, thus being promising candidates as CT contrast agents for clinical applications.
YR 2017
FD 2017
LK http://hdl.handle.net/10668/11203
UL http://hdl.handle.net/10668/11203
LA en
DS RISalud
RD Apr 5, 2025