RT Journal Article
T1 Prevalence of and risk factors for biliary carriage of bacteria showing worrisome and unexpected resistance traits.
A1 Maseda, E.
A1 Maggi, G.
A1 Gomez-Gil, R.
A1 Ruiz, G.
A1 Madero, R.
A1 Garcia-Perea, A.
A1 Aguilar, L.
A1 Gilsanz, F.
A1 Rodriguez-Baño, J.
K1 Bilis
K1 Enfermedades de los conductos biliares Laparoscópica
K1 Factores de riesgo
K1 Farmacorresistencia bacteriana
K1 Prevalencia
AB Data on biliary carriage of bacteria and, specifically, of bacteria with worrisome and unexpected resistance traits (URB) are lacking. A prospective study (April 2010 to December 2011) was performed that included all patients admitted for <48 h for elective laparoscopic cholecystectomy in a Spanish hospital. Bile samples were cultured and epidemiological/clinical data recorded. Logistic regression models (stepwise) were performed using bactobilia or bactobilia by URB as dependent variables. Models (P < 0.001) showing the highest R(2) values were considered. A total of 198 patients (40.4% males; age, 55.3 ± 17.3 years) were included. Bactobilia was found in 44 of them (22.2%). The presence of bactobilia was associated (R(2) Cox, 0.30) with previous biliary endoscopic retrograde cholangiopancreatography (ERCP) (odds ratio [OR], 8.95; 95% confidence interval [CI], 2.96 to 27.06; P < 0.001), previous admission (OR, 2.82; 95% CI, 1.10 to 7.24; P = 0.031), and age (OR, 1.09 per year; 95% CI, 1.05 to 1.12; P < 0.001). Ten out of the 44 (22.7%) patients with bactobilia carried URB: 1 Escherichia coli isolate (CTX-M), 1 Klebsiella pneumoniae isolate (OXA-48), 3 high-level gentamicin-resistant enterococci, 1 vancomycin-resistant Enterococcus isolate, 3 Enterobacter cloacae strains, and 1 imipenem-resistant Pseudomonas aeruginosa strain. Bactobilia by URB (versus those by non-URB) was only associated (R(2) Cox, 0.19) with previous ERCP (OR, 11.11; 95% CI, 1.98 to 62.47; P = 0.006). For analyses of patients with bactobilia by URB versus the remaining patients, previous ERCP (OR, 35.284; 95% CI, 5.320 to 234.016; P < 0.001), previous intake of antibiotics (OR, 7.200; 95% CI, 0.962 to 53.906; P = 0.050), and age (OR, 1.113 per year of age; 95% CI, 1.028 to 1.206; P = 0.009) were associated with bactobilia by URB (R(2) Cox, 0.19; P < 0.001). Previous antibiotic exposure (in addition to age and previous ERCP) was a risk driver for bactobilia by URB. This may have implications in prophylactic/therapeutic measures.
PB American Society for Microbiology
SN 0095-1137
YR 2013
FD 2013-02
LK http://hdl.handle.net/10668/1574
UL http://hdl.handle.net/10668/1574
LA en
NO Maseda E, Maggi G, Gomez-Gil R, Ruiz G, Madero R, Garcia-Perea A, et al. Prevalence of and risk factors for biliary carriage of bacteria showing worrisome and unexpected resistance traits. J. Clin. Microbiol. 2013; 51(2):518-21
NO Journal Article;
DS RISalud
RD Apr 7, 2025