RT Journal Article
T1 A Genome-Wide Association Study on Liver Stiffness Changes during Hepatitis C Virus Infection Cure.
A1 Corma-Gómez, Anaïs
A1 Macías, Juan
A1 Rivero, Antonio
A1 Rivero-Juarez, Antonio
A1 de Los Santos, Ignacio
A1 Reus-Bañuls, Sergio
A1 Morano, Luis
A1 Merino, Dolores
A1 Palacios, Rosario
A1 Galera, Carlos
A1 Fernández-Fuertes, Marta
A1 González-Serna, Alejandro
A1 de Rojas, Itziar
A1 Ruiz, Agustín
A1 Sáez, María E
A1 Real, Luis M
A1 Pineda, Juan A
K1 GWAS
K1 direct-acting antivirals
K1 hepatitis C virus infection
K1 liver stiffness
K1 polymorphisms
K1 sustained virological response
AB Liver stiffness (LS) at sustained virological response (SVR) after direct-acting antivirals (DAA)-based therapy is a predictor of liver events in hepatitis C virus (HCV)-infected patients. The study aim was to identify genetic factors associated with LS changes from the moment of starting anti-HCV therapy to SVR. This prospective study included HCV-infected patients from the GEHEP-011 cohort who achieved SVR with DAA-based therapy, with LS pre-treatment ≥ 9.5 kPa and LS measurement available at SVR. Plink and Magma software were used to carry out genome-wide single-nucleotide polymorphism (SNP)-based and gene-based association analyses, respectively. The ShinyGO application was used for exploring enrichment in Gene Ontology (GO) categories for biological processes. Overall, 242 patients were included. Median (quartile 1, quartile 3) LS values at pre-treatment and at SVR were 16.8 (12, 28) kPa and 12.0 (8.5, 19.3) kPa, respectively. Thirty-five SNPs and three genes reached suggestive association with LS changes from the moment of starting anti-HCV therapy to SVR. GO categories related to DNA packaging complex, DNA conformation change, chromosome organization and chromatin organization were significantly enriched. Our study reports possible genetic factors associated with LS changes during HCV-infection cure. In addition, our results suggest that processes related to DNA conformation are also involved in these changes.
SN 2075-4418
YR 2021
FD 2021-08-20
LK https://hdl.handle.net/10668/27165
UL https://hdl.handle.net/10668/27165
LA en
DS RISalud
RD Feb 24, 2025