RT Journal Article
T1 Impact of Total Parenteral Nutrition on Gut Microbiota in Pediatric Population Suffering Intestinal Disorders.
A1 Cerdo, Tomas
A1 Garcia-Santos, Jose Antonio
A1 Rodriguez-Pöhnlein, Anna
A1 Garcia-Ricobaraza, Maria
A1 Nieto-Ruiz, Ana
A1 G Bermudez, Mercedes
A1 Campoy, Cristina
K1 TPN-associated mucosal atrophy
K1 Gut microbiota dysbiosis
K1 Inflammatory bowel disease (IBD)
K1 Intestinal failure (IF)
K1 Necrotizing enterocolitis (NEC)
K1 Parenteral nutrition-associated liver disease (PNAD)
K1 Pediatric population
K1 Postbiotics
K1 Short bowel syndrome (SBS)
K1 Total parenteral nutrition (TPN)
AB Parenteral nutrition (PN) is a life-saving therapy providing nutritional support in patients with digestive tract complications, particularly in preterm neonates due to their gut immaturity during the first postnatal weeks. Despite this, PN can also result in several gastrointestinal complications that are the cause or consequence of gut mucosal atrophy and gut microbiota dysbiosis, which may further aggravate gastrointestinal disorders. Consequently, the use of PN presents many unique challenges, notably in terms of the potential role of the gut microbiota on the functional and clinical outcomes associated with the long-term use of PN. In this review, we synthesize the current evidence on the effects of PN on gut microbiome in infants and children suffering from diverse gastrointestinal diseases, including necrotizing enterocolitis (NEC), short bowel syndrome (SBS) and subsequent intestinal failure, liver disease and inflammatory bowel disease (IBD). Moreover, we discuss the potential use of pre-, pro- and/or synbiotics as promising therapeutic strategies to reduce the risk of severe gastrointestinal disorders and mortality. The findings discussed here highlight the need for more well-designed studies, and harmonize the methods and its interpretation, which are critical to better understand the role of the gut microbiota in PN-related diseases and the development of efficient and personalized approaches based on pro- and/or prebiotics.
PB MDPI
YR 2022
FD 2022-11-04
LK http://hdl.handle.net/10668/21520
UL http://hdl.handle.net/10668/21520
LA en
NO Cerdó T, García-Santos JA, Rodríguez-Pöhnlein A, García-Ricobaraza M, Nieto-Ruíz A, G Bermúdez M, et al. Impact of Total Parenteral Nutrition on Gut Microbiota in Pediatric Population Suffering Intestinal Disorders. Nutrients. 2022 Nov 6;14(21):4691
DS RISalud
RD Apr 19, 2025