TY  - JOUR
AU  - Pérez-Jiménez, Mercedes M.
AU  - Monje-Moreno, José M.
AU  - Brokate-Llanos, Ana María
AU  - Venegas-Calerón, Mónica
AU  - Sánchez-García, Alicia
AU  - Sansigre, Paula
AU  - Valladares, Amador
AU  - Esteban-García, Sara
AU  - Suárez-Pereira, Irene
AU  - Vitorica, Javier
AU  - Ríos, José Julián
AU  - Artal-Sanz, Marta
AU  - Carrión, Ángel M.
AU  - Muñoz, Manuel J.
PY  - 2021
DO  - 10.1038/s41467-020-20269-y
UR  - http://hdl.handle.net/10668/4311
T2  - Nature Communications
AB  - Aging and fertility are two interconnected processes. From invertebrates to mammals, absence of the germline increases longevity. Here we show that loss of function of sul-2, the Caenorhabditis elegans steroid sulfatase (STS), raises the pool of...
LA  - en
PB  - Nature Publishing Group
KW  - Longevity
KW  - Alzheimer disease
KW  - Fertility
KW  - Aging
KW  - Mutation
KW  - Sensory neurons
KW  - Phenotype
KW  - Testosterone
KW  - Steroids
KW  - Sulfatases
KW  - Longevidad
KW  - Enfermedad de alzheimer
KW  - Fertilidad
KW  - Envejecimiento
KW  - Mutación
KW  - Células receptoras sensoriales
KW  - Fenotipo
KW  - Testosterona
KW  - Esteroides
KW  - Sulfatasas
KW  - Medical Subject Headings::Diseases::Nervous System Diseases::Neurodegenerative Diseases::Tauopathies::Alzheimer Disease
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals::Invertebrates::Helminths::Nematoda::Secernentea::Rhabditida::Rhabditoidea::Caenorhabditis::Caenorhabditis elegans
KW  - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Helminth Proteins::Caenorhabditis elegans Proteins
KW  - Medical Subject Headings::Diseases::Animal Diseases::Disease Models, Animal
KW  - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::Gene Expression Regulation::Epistasis, Genetic
KW  - Medical Subject Headings::Anatomy::Urogenital System::Genitalia::Gonads
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Mice
KW  - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Phenotype
KW  - Medical Subject Headings::Anatomy::Cells::Neurons::Neurons, Afferent::Sensory Receptor Cells
KW  - Medical Subject Headings::Chemicals and Drugs::Polycyclic Compounds::Steroids
KW  - Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Hydrolases::Esterases::Sulfatases::Arylsulfatases::Steryl-Sulfatase
KW  - Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Hydrolases::Esterases::Sulfatases
KW  - Medical Subject Headings::Phenomena and Processes::Physiological Phenomena::Longevity
KW  - Medical Subject Headings::Psychiatry and Psychology::Psychological Phenomena and Processes::Mental Processes::Learning::Cues
KW  - Medical Subject Headings::Anatomy::Cells::Germ Cells
KW  - Medical Subject Headings::Phenomena and Processes::Reproductive and Urinary Physiological Phenomena::Reproductive Physiological Phenomena::Fertility
KW  - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Variation::Mutation
KW  - Medical Subject Headings::Chemicals and Drugs::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Gonadal Hormones::Gonadal Steroid Hormones::Testosterone Congeners::Testosterone
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals
TI  - Steroid hormones sulfatase inactivation extends lifespan and ameliorates age-related diseases
TY  - research article
ER  -