RT Journal Article
T1 Cohort Profile: Design and methods of the PREDIMED-Plus randomized trial.
A1 Martinez-Gonzalez, Miguel A
A1 Buil-Cosiales, Pilar
A1 Corella, Dolores
A1 Bullo, Monica
A1 Fito, Montserrat
A1 Vioque, Jesus
A1 Romaguera, Dora
A1 Martinez, J Alfredo
A1 Wärnberg, Julia
A1 Lopez-Miranda, Jose
A1 Estruch, Ramon
A1 Bueno-Cavanillas, Aurora
A1 Aros, Fernando
A1 Tur, Josep A
A1 Tinahones, Francisco
A1 Serra-Majem, Lluis
A1 Martin, Vicente
A1 Lapetra, Jose
A1 Vazquez, Clotilde
A1 Pinto, Xavier
A1 Vidal, Josep
A1 Daimiel, Lidia
A1 Delgado-Rodriguez, Miguel
A1 Matia, Pilar
A1 Ros, Emilio
A1 Fernandez-Aranda, Fernando
A1 Botella, Cristina
A1 Puy-Portillo, Maria
A1 Lamuela-Raventos, Rosa M
A1 Marcos, Ascension
A1 Saez, Guillermo
A1 Gomez-Gracia, Enrique
A1 Ruiz-Canela, Miguel
A1 Toledo, Estefania
A1 Alvarez-Alvarez, Ismael
A1 Diez-Espino, Javier
A1 Sorli, Jose V
A1 Basora, Josep
A1 Castañer, Olga
A1 Schröder, Helmut
A1 Navarrete-Muñoz, Eva Maria
A1 Zulet, Maria Angeles
A1 Garcia-Rios, Antonio
A1 Salas-Salvado, Jordi
K1 Cardiovascular Diseases
K1 Evidence-Based Medicine
K1 Humans
K1 Multicenter Studies as Topic
K1 Risk Assessment
K1 Sample Size
K1 Time Factors
AB The PREDIMED (in Spanish: PREvención con DIeta  MEDiterránea ) primary prevention trial1–3 reported in 2013 that long-term adherence to an energy-unrestricted Mediterranean diet (MedDiet), supplemented with either extra-virgin olive oil (EVOO) or nuts , reduced cardiovascular disease (CVD). PREDIMED showed a 30% relative reduction in the composite cardiovascular primary endpoint ( stroke , myocardial infarction or cardiovascular death ).2,,3 However, the PREDIMED trial tested only the composition of the diet , but did not test other lifestyle interventions (i.e. energy reduction, increased physical activity (PA) and behavioural modification) frequently applied in the context of the current unprecedented obesity pandemic .4,,5 With the exception of the null results of the Look-AHEAD trial,6 and the successful results of the EXERDIET-HTA study that found improvements in blood pressure , cardio-respiratory fitness and body composition (though they encouraged adherence to an hypocaloric DASH diet , instead of a Mediterranean diet ),7  lifestyle interventions including such components have never been tested in long-term randomized trials using hard cardiovascular events as endpoints.
PB Oxford University Press
YR 2019
FD 2019-04-02
LK https://hdl.handle.net/10668/24502
UL https://hdl.handle.net/10668/24502
LA en
NO Martínez-González MA, Buil-Cosiales P, Corella D, Bulló M, Fitó M, Vioque J, et al. Cohort Profile: Design and methods of the PREDIMED-Plus randomized trial. Int J Epidemiol. 2019 Apr 1;48(2):387-388o.
DS RISalud
RD Apr 7, 2025