RT Journal Article
T1 Assessment of Subclinical Psychotic Symptoms in Patients with Rheumatoid Arthritis and Spondyloarthritis
A1 Prados-Ojeda, Juan L.
A1 Luque-Luque, Rogelio
A1 Gordillo-Urbano, Rafael M.
A1 Guler, Ipek
A1 López-Medina, Clementina
A1 Collantes-Estévez, Eduardo
A1 Escudero-Contreras, Alejandro
K1 Rheumatoid arthritis
K1 Spondyloarthritis
K1 Inflammation
K1 Autoimmunity
K1 Psychotic symptoms
K1 Anxiety
K1 Depression
K1 Artritis reumatoide
K1 Espondiloartritis axial
K1 Inflamación
K1 Autoinmunidad
K1 Manifestaciones neurológicas
K1 Ansiedad
K1 Depresión
AB Inflammatory and autoimmune processes have been associated with the onset of depressive and psychotic symptoms. Rheumatoid arthritis (RA) and spondyloarthritis (SpA) are rheumatic diseases with an inflammatory etiology. A high prevalence of depressive and anxiety-related comorbidity has been reported for both diseases, with no evidence of a greater prevalence of psychosis. The objective of the present study was to evaluate for the first time subclinical psychotic symptoms in patients with RA and SpA. This is a cross-sectional, single-center study including RA and SpA patients, as well as healthy controls. Abnormal psychotic experiences (positive, negative, and depressive symptoms) were evaluated using the Community Assessment of Psychic Experiences (CAPE-42). Functional capacity was evaluated using the Short-Form Health Survey SF-12. We compared the CAPE and SF-12 scores between the three groups. We recruited 385 individuals: 218 with RA, 100 with SpA, and 67 healthy controls. According to the CAPE scale, the frequency of subclinical psychotic symptoms was greater in patients than in healthy controls (RA, 1.90 vs. 1.63, p < 0.001; SpA, 1.88 vs. 1.63, p = 0.001). Distress was also greater in patients than in controls owing to the presence of symptoms. No differences were observed between the three groups for the mental dimension scores in the SF-12 Health Survey (43.75 in RA, 45.54 in SpA, and 43.19 in healthy controls). Our findings point to a greater prevalence of subclinical psychotic symptoms in patients with RA and patients with SpA than in the general population. The results suggest an association between inflammation and depression/subclinical psychotic symptoms.
PB MDPI
YR 2021
FD 2021-08-04
LK http://hdl.handle.net/10668/4307
UL http://hdl.handle.net/10668/4307
LA en
NO Prados-Ojeda JL, Luque-Luque R, Gordillo-Urbano RM, Guler I, López-Medina C, Collantes-Estévez E, et al. Assessment of Subclinical Psychotic Symptoms in Patients with Rheumatoid Arthritis and Spondyloarthritis. J Clin Med. 2021 Aug 4;10(16):3461
DS RISalud
RD Apr 10, 2025