TY - JOUR AU - Gomez-Millan, J AU - Pajares, B AU - Perez-Villa, L AU - Carnero, A AU - Alvarez, M AU - De Luque, V AU - Rivas, F AU - Trigo, J M AU - Toledo, M D AU - Alba, E AU - Medina, J A PY - 2016 DO - 10.1186/s12885-016-2869-x UR - http://hdl.handle.net/10668/10564 T2 - BMC cancer AB - MEK1 (MAP2K1) and MEK2 (MAP2K2) are closely related dual-specificity protein kinases which function by phosphorylating both serine/threonine and tyrosine residues of their substrates ERK1 and ERK2, controlling fundamental cellular processes that... LA - en KW - Head and neck cancer KW - Radiochemotherapy KW - pMEK KW - Adult KW - Aged KW - Biomarkers KW - Chemoradiotherapy KW - Extracellular Signal-Regulated MAP Kinases KW - Female KW - Gene Expression KW - Head and Neck Neoplasms KW - Humans KW - Immunohistochemistry KW - Kaplan-Meier Estimate KW - Male KW - Middle Aged KW - Neoplasm Staging KW - Phosphorylation KW - Prognosis KW - Protein Transport KW - Risk Factors KW - Signal Transduction TI - Subcellular localisation of pMEK has a different prognosis in locally advanced head and neck cancer treated with concomitant radiochemotherapy. TY - research article VL - 16 ER -