RT Journal Article
T1 Clinical and genetic differences between bipolar disorder type 1 and 2 in multiplex families.
A1 Guzman-Parra, Jose
A1 Streit, Fabian
A1 Forstner, Andreas J
A1 Strohmaier, Jana
A1 Gonzalez, Maria Jose
A1 Gil- Flores, Susana
A1 Cabaleiro-Fabeiro, Francisco J
A1 Del-Rio-Noriega, Francisco
A1 Perez- Perez, Fermin
A1 Haro-Gonzalez, Jesus
A1 Orozco-Diaz, Guillermo
A1 de-Diego-Otero, Yolanda
A1 Moreno-Kustner, Berta
A1 Auburger, Georg
A1 Degenhardt, Franziska
A1 Heilmann-Heimbach, Stefanie
A1 Herms, Stefan
A1 Hoffmann, Per
A1 Frank, Josef
A1 Foo, Jerome C
A1 Sirignano, Lea
A1 Witt, Stephanie H
A1 Cichon, Sven
A1 Rivas, Fabio
A1 Mayoral, Fermin
A1 Nothen, Markus M
A1 Andlauer, Till F M
A1 Rietschel, Marcella
K1 Área de Gestión Sanitaria Campo de Gibraltar Oeste
K1 Área de Gestión Sanitaria de Jerez, Costa Noroeste y Sierra de Cádiz
K1 Depression
K1 Disease Progression
K1 Suicidal Ideation
K1 Bipolar Disorder
AB The two major subtypes of bipolar disorder (BD), BD-I and BD-II, are distinguished based on the presence of manic or hypomanic episodes. Historically, BD-II was perceived as a less severe form of BD-I. Recent research has challenged this concept of a severity continuum. Studies in large samples of unrelated patients have described clinical and genetic differences between the subtypes. Besides an increased schizophrenia polygenic risk load in BD-I, these studies also observed an increased depression risk load in BD-II patients. The present study assessed whether such clinical and genetic differences are also found in BD patients from multiplex families, which exhibit reduced genetic and environmental heterogeneity. Comparing 252 BD-I and 75 BD-II patients from the Andalusian Bipolar Family (ABiF) study, the clinical course, symptoms during depressive and manic episodes, and psychiatric comorbidities were analyzed. Furthermore, polygenic risk scores (PRS) for BD, schizophrenia, and depression were assessed. BD-I patients not only suffered from more severe symptoms during manic episodes but also more frequently showed incapacity during depressive episodes. A higher BD PRS was significantly associated with suicidal ideation. Moreover, BD-I cases exhibited lower depression PRS. In line with a severity continuum from BD-II to BD-I, our results link BD-I to a more pronounced clinical presentation in both mania and depression and indicate that the polygenic risk load of BD predisposes to more severe disorder characteristics. Nevertheless, our results suggest that the genetic risk burden for depression also shapes disorder presentation and increases the likelihood of BD-II subtype development.
PB Nature Publishing Group
YR 2021
FD 2021-01-11
LK http://hdl.handle.net/10668/16959
UL http://hdl.handle.net/10668/16959
LA en
NO Guzman-Parra J, Streit F, Forstner AJ, Strohmaier J, González MJ, Gil Flores S, et al. Clinical and genetic differences between bipolar disorder type 1 and 2 in multiplex families. Transl Psychiatry. 2021 Jan 11;11(1):31
DS RISalud
RD Apr 11, 2025