RT Journal Article
T1 Oxidative stress influence on renal dysfunction in patients with obstructive jaundice: A case and control prospective study.
A1 Martínez-Cecilia, David
A1 Reyes-Díaz, María
A1 Ruiz-Rabelo, Juan
A1 Gomez-Alvarez, Manuel
A1 Villanueva, Carmen Muñoz
A1 Álamo, José
A1 Muntané, Jordi
A1 Padillo, Francisco Javier
K1 Acute renal failure
K1 Cancer
K1 Obstructive jaundice
K1 Oxidative stress
AB Obstructive Jaundice (OJ) is associated with a significant risk of developing acute renal failure (ARF). The involvement of oxidative stress in the development of cholestasis has been demonstrated in different experimental models. However, its role in the morbidity of human cholestasis is far to be elucidated. The aim of the study was the evaluation of oxidative stress markers in blood from patients with OJ and its relation to complications and benign/malignant evolution of cholestasis. A prospective cross-sectional study of 105 patients with OJ and 34 control subjects were included. Several markers of liver function and oxidative stress, such as lipoperoxides (LPO), as well as reduced glutathione (GSH), catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities were assessed. The patients with OJ showed a marked increase in plasma levels of LPO, SOD and GSH, while GSH-Px levels were decreased. The increase in lipid peroxidation products and the depletion of SOD activity in blood were also related to renal dysfunction. The highest level of LPO was associated with malignant etiology of the disease. The logistic regression analysis showed that the age of the patient and the levels of LPO in blood were predictors of renal dysfunction in OJ patients. This study demonstrates a correlation between oxidative stress and renal dysfunction patients with OJ.
YR 2015
FD 2015-12-29
LK http://hdl.handle.net/10668/9740
UL http://hdl.handle.net/10668/9740
LA en
DS RISalud
RD Apr 11, 2025