RT Journal Article
T1 An international working group consensus report for the prioritization of molecular biomarkers for Ewing sarcoma.
A1 Shulman, David S
A1 Whittle, Sarah B
A1 Surdez, Didier
A1 Bailey, Kelly M
A1 de-Alava, Enrique
A1 Yustein, Jason T
A1 Shlien, Adam
A1 Hayashi, Masanori
A1 Bishop, Alexander J R
A1 Crompton, Brian D
A1 DuBois, Steven G
A1 Shukla, Neerav
A1 Leavey, Patrick J
A1 Lessnick, Stephen L
A1 Kovar, Heinrich
A1 Delattre, Olivier
A1 Grünewald, Thomas G P
A1 Antonescu, Cristina R
A1 Roberts, Ryan D
A1 Toretsky, Jeffrey A
A1 Tirode, Franck
A1 Gorlick, Richard
A1 Janeway, Katherine A
A1 Reed, Damon
A1 Lawlor, Elizabeth R
A1 Grohar, Patrick J
K1 Cancer genetics
K1 Molecular medicine
K1 Prognostic markers
K1 Sarcoma
AB The advent of dose intensified interval compressed therapy has improved event-free survival for patients with localized Ewing sarcoma (EwS) to 78% at 5 years. However, nearly a quarter of patients with localized tumors and 60-80% of patients with metastatic tumors suffer relapse and die of disease. In addition, those who survive are often left with debilitating late effects. Clinical features aside from stage have proven inadequate to meaningfully classify patients for risk-stratified therapy. Therefore, there is a critical need to develop approaches to risk stratify patients with EwS based on molecular features. Over the past decade, new technology has enabled the study of multiple molecular biomarkers in EwS. Preliminary evidence requiring validation supports copy number changes, and loss of function mutations in tumor suppressor genes as biomarkers of outcome in EwS. Initial studies of circulating tumor DNA demonstrated that diagnostic ctDNA burden and ctDNA clearance during induction are also associated with outcome. In addition, fusion partner should be a pre-requisite for enrollment on EwS clinical trials, and the fusion type and structure require further study to determine prognostic impact. These emerging biomarkers represent a new horizon in our understanding of disease risk and will enable future efforts to develop risk-adapted treatment.
PB Nature Publishing Group
SN 2397-768X
YR 2022
FD 2022-09-17
LK http://hdl.handle.net/10668/19633
UL http://hdl.handle.net/10668/19633
LA en
NO Shulman DS, Whittle SB, Surdez D, Bailey KM, de Álava E, Yustein JT, et al. An international working group consensus report for the prioritization of molecular biomarkers for Ewing sarcoma. NPJ Precis Oncol. 2022 Sep 17;6(1):65.
DS RISalud
RD Apr 10, 2025