RT Journal Article
T1 Epidemiology of human papillomavirus-associated anogenital cancers in Granada: a three-decade population-based study
A1 Dabán-López, Pablo
A1 Fernández-Martínez, Nicolás Francisco
A1 Petrova, Dafina
A1 Rodríguez-Barranco, Miguel
A1 Jimenez-Moleon, JoseJ.
A1 Gutierrez, Javier
A1 Sanchez-Perez, Maria-Jose
K1 Anogenital cancer
K1 Cervical cancer
K1 Epidemiology
K1 Human papillomavirus
K1 Incidence
K1 Mortality
K1 Survival
K1 Time trends
AB Introduction: HPV infection is a common risk factor for all anogenital cancers. However, there are important differences in the epidemiology of anogenital cancers and these have not been compared considering diverse epidemiological indicators over a long period of time. To fill this gap, we investigated incidence, mortality, and survival trends of anogenital cancers over a period of three decades.Methods: We conducted an observational registry-based study using data from the population-based cancer registry of Granada in southern Spain. We collected data on all incident cases of anogenital cancer (cervical, anal, penile, vulvar, and vaginal cancer) diagnosed between 1985 and 2017. We calculated crude and age-standardized incidence and mortality rates, and 1, 3, and 5-year overall and net survival. We further conducted time-trend analysis calculating annual percent changes (APC) for each cancer site.Results: The incidence of anogenital cancers decreased slightly during the past 30 years, with the exception of vulvar cancer, where a slight increase was observed. Mortality decreased significantly for cervical cancer over the study period but increased non-significantly for the remaining cancer sites. Survival rates were similar to those reported in comparable countries and increased for cervical and vulvar cancer.Discussion: Cervical cancer was the greatest contributor to the burden of anogenital cancers and showed a marked improvement in all indicators in comparison to the remaining cancer sites.
PB Frontiers media
SN 2296-2565
YR 2023
FD 2023-09-14
LK https://hdl.handle.net/10668/23297
UL https://hdl.handle.net/10668/23297
LA en
NO Dabán-López P, Fernández-Martínez NF, Petrova D, Rodríguez-Barranco M, Jiménez-Moleón JJ, Gutierrez J et al. Epidemiology of human papillomavirus-associated anogenital cancers in Granada: a three-decade population-based study. Front Public Health. 2023 Sep 14;11:1205170
NO This work was partially supported by the Ministry of Economy and Competitiveness and the National Institute of Health: Instituto de Salud Carlos III (ISCIII) - PI18/01593 EU/FEDER and the Asociación Española Contra el Cáncer (AECC) (PROYE20023SÁNC).
DS RISalud
RD Apr 6, 2025