RT Journal Article
T1 Serum apolipoprotein A1 and haptoglobin, in patients with suspected drug-induced liver injury (DILI) as biomarkers of recovery.
A1 Peta, Valentina
A1 Tse, Chantal
A1 Perazzo, Hugo
A1 Munteanu, Mona
A1 Ngo, Yen
A1 Ngo, An
A1 Ramanujam, Nittia
A1 Verglas, Lea
A1 Mallet, Maxime
A1 Ratziu, Vlad
A1 Thabut, Dominique
A1 Rudler, Marika
A1 Thibault, Vincent
A1 Schuppe-Koistinen, Ina
A1 Bonnefont-Rousselot, Dominique
A1 Hainque, Bernard
A1 Imbert-Bismut, Françoise
A1 Merz, Michael
A1 Kullak-Ublick, Gerd
A1 Andrade, Raul
A1 van Boemmel, Florian
A1 Schott, Eckart
A1 Poynard, Thierry
A1 Drug Induced Liver Injury- Groupe Hospitalier Pitié-Salpêtrière, 
A1 Drug Induced Liver Group of the Injury Safer and Faster Evidence-based Translation consortium, 
AB There is a clear need for better biomarkers of drug-induced-liver-injury (DILI). We aimed to evaluate the possible prognostic value of ActiTest and FibroTest proteins apoliprotein-A1, haptoglobin and alpha-2-macroglobulin, in patients with DILI. We analyzed cases and controls included in the IMI-SAFE-T-DILI European project, from which serum samples had been stored in a dedicated biobank. The analyses of ActiTest and FibroTest had been prospectively scheduled. The primary objective was to analyze the performance (AUROC) of ActiTest components as predictors of recovery outcome defined as an ALT  After adjudication, 154 patients were considered to have DILI and 22 were considered to have acute liver injury without DILI. A multivariate regression analysis (ActiTest-DILI patent pending) combining the ActiTest components without BILI and ALT (used as references), apolipoprotein-A1, haptoglobin, alpha-2-macroglobulin and GGT, age and gender, resulted in a significant prediction of recovery with 67.0% accuracy (77/115) and an AUROC of 0.724 (P We identified that apolipoprotein-A1 and haptoglobin had significant predictive values for the prediction of recovery at 12 weeks in DILI, enabling the construction of a new prognostic panel, the DILI-ActiTest, which needs to be independently validated.
YR 2017
FD 2017-12-29
LK http://hdl.handle.net/10668/11960
UL http://hdl.handle.net/10668/11960
LA en
DS RISalud
RD Apr 10, 2025