RT Journal Article
T1 Academic collaborative models fostering the translation of physiological in vitro systems from basic research into drug discovery.
A1 Silvestri, Alessandra
A1 Vicente, Francisca
A1 Vicent, María J
A1 Stechmann, Bahne
A1 Fecke, Wolfgang
AB The success of preclinical drug discovery strongly relies on the ability of experimental models to resemble human pathophysiology. The number of compounds receiving approval for clinical use is limited, and this has led to the development of more physiologically relevant cellular models aimed at making preclinical results more prone to be successfully translated into clinical use. In this review, we summarize the technologies available in the field of high-throughput screening (HTS) using complex cellular models, and describe collaborative initiatives, such as EU-OPENSCREEN, which can efficiently support researchers to easily access state-of-the-art chemical biology platforms for improving the drug discovery process.
YR 2021
FD 2021-03-04
LK http://hdl.handle.net/10668/17322
UL http://hdl.handle.net/10668/17322
LA en
DS RISalud
RD Apr 17, 2025