RT Journal Article
T1 Genetic polymorphisms of RANTES, IL1-A, MCP-1 and TNF-A genes in patients with prostate cancer
A1 Sáenz-López, Pablo
A1 Carretero, Rafael
A1 Cózar, José Manuel
A1 Romero, José Maria
A1 Canton, Julia
A1 Vilchez, José Ramón
A1 Tallada, Miguel
A1 Garrido, Federico
A1 Ruiz-Cabello, Francisco
K1 Anciano
K1 Estudios de Casos y Controles
K1 Quimiocina CCL2
K1 Quimiocina CCL5
K1 Frecuencia de los Genes
K1 Predisposición Genética a la Enfermedad
K1 Humanos
K1 Interleucina-1alfa
K1 Masculino
K1 Mediana Edad
K1 Polimorfismo Genético
K1 Regiones Promotoras Genéticas
K1 Neoplasias de la Próstata
K1 Factores de Riesgo
K1 Factor de Necrosis Tumoral alfa
AB BACKGROUNDInflammation has been implicated as an etiological factor in several human cancers, including prostate cancer. Allelic variants of the genes involved in inflammatory pathways are logical candidates as genetic determinants of prostate cancer risk. The purpose of this study was to investigate whether single nucleotide polymorphisms of genes that lead to increased levels of pro-inflammatory cytokines and chemokines are associated with an increased prostate cancer risk.METHODSA case-control study design was used to test the association between prostate cancer risk and the polymorphisms TNF-A-308 A/G (rs 1800629), RANTES-403 G/A (rs 2107538), IL1-A-889 C/T (rs 1800587) and MCP-1 2518 G/A (rs 1024611) in 296 patients diagnosed with prostate cancer and in 311 healthy controls from the same area.RESULTSDiagnosis of prostate cancer was significantly associated with TNF-A GA + AA genotype (OR, 1.61; 95% CI, 1.09-2.64) and RANTES GA + AA genotype (OR, 1.44; 95% CI, 1.09-2.38). A alleles in TNF-A and RANTES influenced prostate cancer susceptibility and acted independently of each other in these subjects. No epistatic effect was found for the combination of different polymorphisms studied. Finally, no overall association was found between prostate cancer risk and IL1-A or MCP-1 polymorphisms.CONCLUSIONOur results and previously published findings on genes associated with innate immunity support the hypothesis that polymorphisms in proinflammatory genes may be important in prostate cancer development.
PB BioMed Central
YR 2008
FD 2008-12-19
LK http://hdl.handle.net/10668/602
UL http://hdl.handle.net/10668/602
LA en
NO Sáenz-López P, Carretero R, Cózar JM , Romero JM, Canton J, Vilchez JR et al. Genetic polymorphisms of RANTES, IL1-A, MCP-1 and TNF-A genes in patients with prostate cancer. BMC Cancer. 2008 Dec 19;8:382.
NO Journal Article; Research Support, Non-U.S. Gov't;
DS RISalud
RD Apr 6, 2025