%0 Journal Article
%A Sáenz-López, Pablo
%A Carretero, Rafael
%A Cózar, José Manuel
%A Romero, José Maria
%A Canton, Julia
%A Vilchez, José Ramón
%A Tallada, Miguel
%A Garrido, Federico
%A Ruiz-Cabello, Francisco
%T Genetic polymorphisms of RANTES, IL1-A, MCP-1 and TNF-A genes in patients with prostate cancer
%D 2008
%U http://hdl.handle.net/10668/602
%X BACKGROUNDInflammation has been implicated as an etiological factor in several human cancers, including prostate cancer. Allelic variants of the genes involved in inflammatory pathways are logical candidates as genetic determinants of prostate cancer risk. The purpose of this study was to investigate whether single nucleotide polymorphisms of genes that lead to increased levels of pro-inflammatory cytokines and chemokines are associated with an increased prostate cancer risk.METHODSA case-control study design was used to test the association between prostate cancer risk and the polymorphisms TNF-A-308 A/G (rs 1800629), RANTES-403 G/A (rs 2107538), IL1-A-889 C/T (rs 1800587) and MCP-1 2518 G/A (rs 1024611) in 296 patients diagnosed with prostate cancer and in 311 healthy controls from the same area.RESULTSDiagnosis of prostate cancer was significantly associated with TNF-A GA + AA genotype (OR, 1.61; 95% CI, 1.09-2.64) and RANTES GA + AA genotype (OR, 1.44; 95% CI, 1.09-2.38). A alleles in TNF-A and RANTES influenced prostate cancer susceptibility and acted independently of each other in these subjects. No epistatic effect was found for the combination of different polymorphisms studied. Finally, no overall association was found between prostate cancer risk and IL1-A or MCP-1 polymorphisms.CONCLUSIONOur results and previously published findings on genes associated with innate immunity support the hypothesis that polymorphisms in proinflammatory genes may be important in prostate cancer development.
%K Anciano
%K Estudios de Casos y Controles
%K Quimiocina CCL2
%K Quimiocina CCL5
%K Frecuencia de los Genes
%K Predisposición Genética a la Enfermedad
%K Humanos
%K Interleucina-1alfa
%K Masculino
%K Mediana Edad
%K Polimorfismo Genético
%K Regiones Promotoras Genéticas
%K Neoplasias de la Próstata
%K Factores de Riesgo
%K Factor de Necrosis Tumoral alfa
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