%0 Journal Article
%A Morales-Conde, Macarena
%A López-Ibáñez, Natividad
%A Calvete-Candenas, Julio
%A Mendonça, Francisco Manuel Ildefonso
%T Fulvestrant-induced toxic epidermal necrolysis.
%D 2019
%U http://hdl.handle.net/10668/13967
%X Toxic epidermal necrolysis is a condition with massive keratinocyte apoptosis, and it is associated with high mortality rates. Fulvestrant, an estrogen receptor antagonist, is indicated in the treatment of estrogen receptor-positive metastatic breast cancer in postmenopausal women. To our knowledge, this is the first described case of toxic epidermal necrolysis due to fulvestrant. A 56-year-old woman received 500 mg of intramuscular fulvestrant monthly for metastatic ductal carcinoma of the breast. Five days after the first dose, the patient presented with a maculopapular rash that evolved to blisters, and a detachment of the epidermis in over 30% of the total body surface area. Histological analysis was compatible with toxic epidermal necrolysis. Fulvestrant was discontinued, topical management and supportive care were initiated.
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