RT Journal Article
T1 An Updated View of the Trypanosoma cruzi Life Cycle: Intervention Points for an Effective Treatment.
A1 Martin-Escolano, Javier
A1 Marin, Clotilde
A1 Rosales, Maria J
A1 Tsaousis, Anastasios D
A1 Medina-Carmona, Encarnacion
A1 Martin-Escolano, Ruben
K1 Chagas disease
K1 Trypanosoma cruzi
K1 drug discovery
K1 evolution model
K1 genetic diversity
K1 life cycle
K1 morphological forms
K1 target product profile
K1 tropism
AB Chagas disease (CD) is a parasitic, systemic, chronic, and often fatal illness caused by infection with the protozoan Trypanosoma cruzi. The World Health Organization classifies CD as the most prevalent of poverty-promoting neglected tropical diseases, the most important parasitic one, and the third most infectious disease in Latin America. Currently, CD is a global public health issue that affects 6-8 million people. However, the current approved treatments are limited to two nitroheterocyclic drugs developed more than 50 years ago. Many efforts have been made in recent decades to find new therapies, but our limited understanding of the infection process, pathology development, and long-term nature of this disease has made it impossible to develop new drugs, effective treatment, or vaccines. This Review aims to provide a comprehensive update on our understanding of the current life cycle, new morphological forms, and genetic diversity of T. cruzi, as well as identify intervention points in the life cycle where new drugs and treatments could achieve a parasitic cure.
PB American Chemical Society
YR 2022
FD 2022-06-02
LK http://hdl.handle.net/10668/22596
UL http://hdl.handle.net/10668/22596
LA en
NO Martín-Escolano J, Marín C, Rosales MJ, Tsaousis AD, Medina-Carmona E, Martín-Escolano R. An Updated View of the Trypanosoma cruzi Life Cycle: Intervention Points for an Effective Treatment. ACS Infect Dis. 2022 Jun 10;8(6):1107-1115.
DS RISalud
RD Apr 7, 2025