RT Journal Article
T1 Population Distributions of Thymic Function in Adults: Variation by Sociodemographic Characteristics and Health Status.
A1 Feinstein, Lydia
A1 Ferrando-Martínez, Sara
A1 Leal, Manuel
A1 Zhou, Xuan
A1 Sempowski, Gregory D
A1 Wildman, Derek E
A1 Uddin, Monica
A1 Aiello, Allison E
AB The thymus is critical for mounting an effective immune response and maintaining health. However, epidemiologic studies characterizing thymic function in the population setting are lacking. Using data from 263 adults in the Detroit Neighborhood Health Study, we examined thymic function as measured by the number of signal joint T-cell receptor excision circles (sjTREC) and assessed associations with established indicators of physiological health. Overall, increasing age and male gender were significantly associated with reduced thymic function. Adjusting for covariates, individuals with elevated levels of the pro-inflammatory biomarkers C-reactive protein (β: -0.50 [95% CI: -0.82, -0.18] for moderate elevation, β: -0.29 [95% CI: -0.59, 0.00] for high elevation) and interleukin-6 (β: -0.60 [95% CI: -0.92, -0.28] for moderate elevation, β: -0.43 [95% CI: -0.77, -0.08] for severe elevation) also had lower thymic function. Compared to individuals with a BMI
YR 2016
FD 2016
LK http://hdl.handle.net/10668/10209
UL http://hdl.handle.net/10668/10209
LA en
DS RISalud
RD Apr 8, 2025