RT Journal Article
T1 TFG-β Nuclear Staining as a Potential Relapse Risk Factor in Early-Stage Non-Small-Cell Lung Cancer.
A1 Cardenas-Quesada, Nuria
A1 Diaz-Beltran, Leticia
A1 Rosa-Garrido, Carmen
A1 Marquez-Lobo, Belgica
A1 Sabio-Gonzalez, Adela
A1 Luque-Barona, Rafael J
A1 Nuñez, Maria Isabel
A1 Sanchez-Rovira, Pedro
K1 PD-L1
K1 TGF-β
K1 TILs
K1 checkpoint inhibition
K1 early-stage lung cancer
K1 prognostic factors
AB Nowadays, the impact of the tumor-immune microenvironment (TME) in non-small-cell lung cancer (NSCLC) prognosis and treatment response remains unclear. Thus, we evaluated the expression of PD-L1, tumor-infiltrating lymphocytes (TILs), and transforming growth factor beta (TGF-β) in NSCLC to identify differences in TME, detect possible new prognostic factors, and assess their relationship. We retrospectively analyzed 55 samples from patients who underwent NSCLC surgery and had over a 5-year follow-up. PD-L1 expression was determined by immunohistochemistry following standard techniques. The presence of TILs was evaluated at low magnification and classified into two categories, “intense” and “non-intense”. Cytoplasmic TGF-β staining visualization was divided into four categories, and unequivocal nuclear staining in >1% of viable tumor cells was defined as “present” or “absent”. Our aim was to identify differences in disease-free survival (DFS) and overall survival (OS). Tumor stage was the only objective prognostic factor for OS. PD-L1 expression and the presence of TILs had no prognostic impact, neither their combination. There seems to be a lower expression of PD-L1 and a higher expression of TILs in early stages of the disease. Our TGF-β nuclear staining analysis was promising, since it was associated with worse DFS, revealing this protein as a possible prognostic biomarker of recurrence for resectable NSCLC.
PB MDPI AG
YR 2022
FD 2022-11-06
LK http://hdl.handle.net/10668/21214
UL http://hdl.handle.net/10668/21214
LA en
NO Cárdenas-Quesada N, Díaz-Beltrán L, Rosa-Garrido C, Márquez-Lobo B, Sabio-González A, Luque-Barona RJ, et al. TFG-β Nuclear Staining as a Potential Relapse Risk Factor in Early-Stage Non-Small-Cell Lung Cancer. Int J Mol Sci. 2022 Nov 9;23(22):13780.
DS RISalud
RD Apr 10, 2025