RT Journal Article
T1 Effects of dietary fat on insulin secretion in subjects with the metabolic syndrome.
A1 Gulseth, Hanne L
A1 Gjelstad, Ingrid M F
A1 Tiereny, Audrey C
A1 McCarthy, Danielle
A1 Lovegrove, Julie A
A1 Defoort, Catherine
A1 Blaak, Ellen E
A1 Lopez-Miranda, Jose
A1 Dembinska-Kiec, Aldona
A1 Riserus, Ulf
A1 Roche, Helen M
A1 Drevon, Christian A
A1 Birkeland, Kåre I
K1 Insulin secretion
K1 Male
K1 Metabolic syndrome
K1 Middle aged
AB Objective Impaired insulin secretion and action contribute to the development of type 2 diabetes. Dietary fat modification may improve insulin sensitivity, whereas the effect on insulin secretion is unclear. We investigated the effect of dietary fat modification on insulin secretion in subjects with the metabolic syndrome. Design In a 12-week pan-European parallel, randomized controlled dietary intervention trial (LIPGENE), 486 subjects were assigned to four isoenergetic diets: high-fat diets rich in saturated fat (HSFA) or monounsaturated fat (HMUFA) or low-fat, high-complex carbohydrate diets with (LFHCC n-3) or without (LFHCC control) 1.2 g/day of n-3 PUFA supplementation. Insulin secretion was estimated as acute insulin response to glucose (AIRg) and disposition index (DI), modeled from an intravenous glucose tolerance test. Results There were no overall effect of the dietary intervention on AIRg and DI in the total cohort, in neither the high-fat nor LFHCC groups. We observed significant diet*fasting glucose category interactions for AIRg (P = 0.021) and DI (P = 0.001) in the high-fat groups. In subjects with normal fasting glucose and preserved first phase insulin secretion, the HMUFA diet increased, whereas the HSFA diet reduced AIRg (P = 0.015) and DI (P = 0.010). Conclusions The effects of dietary fat modification on insulin secretion were minor, and only evident in normoglycemic subjects. In this case, the HMUFA diet improved AIRg and DI, as compared to the HSFA diet.
PB Oxford University Press
YR 2019
FD 2019
LK http://hdl.handle.net/10668/13737
UL http://hdl.handle.net/10668/13737
LA en
NO Gulseth HL, Gjelstad IMF, Tiereny AC, McCarthy D, Lovegrove JA, Defoort C, et al. Effects of dietary fat on insulin secretion in subjects with the metabolic syndrome. Eur J Endocrinol. 2019 May 1;180(5):321-328
DS RISalud
RD Apr 11, 2025