RT Journal Article
T1 Permanent pacemaker implantation after transcatheter aortic valve implantation: impact on late clinical outcomes and left ventricular function.
A1 Urena, Marina
A1 Webb, John G
A1 Tamburino, Corrado
A1 Muñoz-García, Antonio J
A1 Cheema, Asim
A1 Dager, Antonio E
A1 Serra, Vicenç
A1 Amat-Santos, Ignacio J
A1 Barbanti, Marco
A1 Immè, Sebastiano
A1 Alonso Briales, Juan H
A1 Benítez, Luis Miguel
A1 Al Lawati, Hatim
A1 Cucalón, Ángela María
A1 García del Blanco, Bruno
A1 López, Javier
A1 Dumont, Eric
A1 Delarochellière, Robert
A1 Ribeiro, Henrique B
A1 Nombela-Franco, Luis
A1 Philippon, François
A1 Rodés-Cabau, Josep
K1 Aortic stenosis
K1 Death, sudden, cardiac
K1 Heart valves
K1 Pacemaker, artificial
K1 Válvulas cardíacas
K1 Cateterismo cardíaco
K1 Estudios de cohortes
K1 Implantación de prótesis de válvulas cardíacas
K1 Marcapaso artificial
K1 Factores de tiempo
K1 Resultado del tratamiento
K1 Función ventricular izquierda
K1 Anciano
AB BACKGROUNDVery few data exist on the clinical impact of permanent pacemaker implantation (PPI) after transcatheter aortic valve implantation. The objective of this study was to assess the impact of PPI after transcatheter aortic valve implantation on late outcomes in a large cohort of patients.METHODS AND RESULTSA total of 1556 consecutive patients without prior PPI undergoing transcatheter aortic valve implantation were included. Of them, 239 patients (15.4%) required a PPI within the first 30 days after transcatheter aortic valve implantation. At a mean follow-up of 22±17 months, no association was observed between the need for 30-day PPI and all-cause mortality (hazard ratio, 0.98; 95% confidence interval, 0.74-1.30; P=0.871), cardiovascular mortality (hazard ratio, 0.81; 95% confidence interval, 0.56-1.17; P=0.270), and all-cause mortality or rehospitalization for heart failure (hazard ratio, 1.00; 95% confidence interval, 0.77-1.30; P=0.980). A lower rate of unexpected (sudden or unknown) death was observed in patients with PPI (hazard ratio, 0.31; 95% confidence interval, 0.11-0.85; P=0.023). Patients with new PPI showed a poorer evolution of left ventricular ejection fraction over time (P=0.017), and new PPI was an independent predictor of left ventricular ejection fraction decrease at the 6- to 12-month follow-up (estimated coefficient, -2.26; 95% confidence interval, -4.07 to -0.44; P=0.013; R(2)=0.121).CONCLUSIONSThe need for PPI was a frequent complication of transcatheter aortic valve implantation, but it was not associated with any increase in overall or cardiovascular death or rehospitalization for heart failure after a mean follow-up of ≈2 years. Indeed, 30-day PPI was a protective factor for the occurrence of unexpected (sudden or unknown) death. However, new PPI did have a negative effect on left ventricular function over time.
PB Lippincott  Williams & Wilkins
SN 0009-7322
YR 2014
FD 2014-03-18
LK http://hdl.handle.net/10668/1839
UL http://hdl.handle.net/10668/1839
LA en
NO Urena M, Webb JG, Tamburino C, Muñoz-García AJ, Cheema A, Dager AE, et al. Permanent pacemaker implantation after transcatheter aortic valve implantation: impact on late clinical outcomes and left ventricular function. Circulation. 2014; 129(11):1233-1243
NO Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't;
DS RISalud
RD Apr 14, 2025